Comparative pathogenicity of three genetically distinct Trypanosoma congolense-types in inbred Balb/c mice
Comparative pathogenicity of three genetically distinct Trypanosoma congolense-types in inbred Balb/c mice
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DOI：
10.1016/s0304-4017(01)00609-4
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发表时间：
2002-04-30
影响因子：
2.6
通讯作者：
Desquesnes, M
中科院分区：
文献类型：
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作者：
Bengaly, Z;Sidibe, I;Desquesnes, M
用刚果锥虫的三个克隆（Sam.28.1、Dind.3.1和K60.1A）感染近交系Balb/c小鼠，分别对应于该物种内定义的三种遗传上不同的类型（萨凡纳、森林和基利菲），目的是比较它们的致病性，以便更好地了解非洲锥虫病的流行病学。另一个萨凡纳型的克隆，IL 3000，也同时进行了测试，以研究可能的应变变化。萨凡纳型的两个克隆都被发现具有极强的毒性，食欲不振，毛发粗糙，呼吸急促，嗜睡，寄生虫血症在感染后3-5天迅速发展到第一个高峰，森林型和基利菲型的克隆株毒力低，慢性感染，在整个感染过程中，症状逐渐不明显;每个实验组中只有一只小鼠死亡。(C)2002 Elsevier Science B. V.保留所有权利。
Inbred Balb/c mice were infected with three clones of Trypanosoma congolense (Sam.28.1, Dind.3.1 and K60.1A) corresponding, respectively, to the three genetically distinct types (savannah, forest and kilifi) defined within this species, for the purpose of comparing their pathogenicity for a better understanding of the epidemiology of African trypanosomosis. Another clone of savannah type, IL 3000, was also tested simultaneously to study a probable strain variation. Both the clones of savannah type were found of extreme virulence with loss of appetite, rough hair, rapid respiration, lethargy, and all mice died within a week.Parasitaemias evolved rapidly to the first peak by day 3-5 post-inoculation without any remission and the course of disease was correlated positively with the prepatent period.The clones of the forest type and the kilifi type were of low virulence with chronic infection and symptoms progressively less patent throughout the infection; only one mouse died in each experimental group. (C) 2002 Elsevier Science B.V. All rights reserved.