Antimicrobial and SOD activities of novel transition metal ternary complexes of iminodiacetic acid containing alpha-diimine as auxiliary ligand.
Antimicrobial and SOD activities of novel transition metal ternary complexes of iminodiacetic acid containing alpha-diimine as auxiliary ligand.
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DOI：
10.1016/j.ejmech.2009.01.025
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发表时间：
2009-06
影响因子：
6.7
通讯作者：
Z. A. Siddiqi;M. Shahid;M. Khalid;Sarvendra Kumar
中科院分区：
文献类型：
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作者：
Z. A. Siddiqi;M. Shahid;M. Khalid;Sarvendra Kumar
含有α-二亚胺辅助配体的三元配合物已被广泛用作几种单核和多核金属酶的模型。在邻菲咯啉（Phen）存在下，Cu（OAc）2或MCl 2（M=Co，Ni，Cr）与亚氨基二乙酸（H2 IDA）反应，合成了新型三元配合物[M（IDA）（Phen）H2O]·xH 2 O（x=2，3或4），其化学结构和成键经IR，FAB-Mass，1H，13 CNMR，EPR光谱和元素分析确证.对大肠杆菌（K-12）、枯草芽孢杆菌（MTCC 121）、金黄色葡萄球菌（IOA-SA-22）、鼠伤寒沙门氏菌（MTCC 98）、白色念珠菌（Candida albicans）、烟曲霉（Aspergillus fumigatus）和马尔尼菲青霉（Penicillium marneffei）（来自AMU农学院微生物学系分离株）进行了抗菌活性研究，结果表明，该菌株具有显著的抗菌活性。通过NBT测定法评估Cu（II）络合物的超氧化物歧化酶活性。[Cu（IDA）（Phen）H_2O]·2H_2O的X射线单晶结构为三斜晶系，空间群为P-1，结构参数为：a=6.745（5），B=10.551（5），c=11.414（5）nm，α=95.770（5），β=91.396（5），γ=92.518（5）°，存在大量的氢键和π-π堆积作用，形成超分子骨架。
Ternary complexes containing an α-diimine auxiliary ligand have been widely used as models for several mono and polynuclear metal enzymes. The present ternary complexes [M(IDA)(Phen)H2O]·xH2O (x=2, 3 or 4) were prepared as novel antimicrobial agents employing reactions of Cu(OAc)2or MCl2(M=Co, Ni, Cr) with iminodiacetic acid (H2IDA) in the presence of 1,10-phenanthroline (Phen), whose chemical structure and bonding were elucidated by IR, FAB-Mass,1H,13C NMR, EPR spectral and elemental analyses. The antimicrobial activities against Escherichia coli (K-12), Bacillus subtilis (MTCC 121), Staphylococcus aureus (IOA-SA-22), Salmonella typhimurium (MTCC 98), Candida albicans, Aspergillus fumigatus and Penicillium marneffei (isolates from Department of Microbiology, Faculty of Agricultural Science, AMU) were investigated and significant activities were obtained. The superoxide dismutase activity of the Cu(II) complex was assessed by NBT assay. The single crystal X-ray structure for [Cu(IDA)(Phen)H2O]·2H2O indicates a triclinic unit cell in P-1 space group with structural parameters, a=6.745(5), b=10.551(5), c=11.414(5)Å, α=95.770(5), β=91.396(5), γ=92.518(5)° and presence of an extensive H-bonding and π–π stacking interactions which generate a supramolecular framework.