Enantioselective palladium-catalyzed addition of malonates to 3,3-difluoropropenes
Enantioselective palladium-catalyzed addition of malonates to 3,3-difluoropropenes
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DOI：
10.1016/j.tet.2018.08.034
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发表时间：
2018-10-11
期刊：
影响因子：
2.1
通讯作者：
Paquin, Jean-Francois
中科院分区：
文献类型：
--
作者：
Drouin, Myriam;Paquin, Jean-Francois
在β位带有丙二酸酯单元的单氟烯烃可以通过二酯对映选择性加成到3，3-二氟丙烯上来合成。研究了关于3，3-二氟丙烯的烯烃的几何形状和取代基以及丙二酸酯的烷基的反应性的差异，并确定了限制。该反应也用不同的3，3-二氟丙烯进行。还完成了新官能化的单氟烯烃的进一步合成转化。(C)2018爱思唯尔有限公司版权所有
Monofluoroalkenes bearing a malonate unit at the beta position can be synthesized by the enantioselective addition of diesters to 3,3-difluoropropenes. The difference in reactivity regarding the geometry and the substituents of the alkene of the 3,3-difluoropropenes, as well as the alkyl groups of the malonates, was studied and limitations were identified. The reaction was also performed with different 3,3-difluoropropenes. Further synthetic transformations of a newly functionalized monofluoroalkene were also accomplished. (C) 2018 Elsevier Ltd. All rights reserved.