BLOOD SUGAR REGULATION IN HAGFISH MYXINE GLUTINOSA
BLOOD SUGAR REGULATION IN HAGFISH MYXINE GLUTINOSA
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DOI：
10.1016/s0016-6480(66)80021-7
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发表时间：
1966-01-01
影响因子：
2.7
通讯作者：
MATTY, AJ
中科院分区：
文献类型：
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作者：
FALKMER, S;MATTY, AJ
在3周的时间里，禁食粘液粘液组的血糖水平没有下降。在8oC葡萄糖负荷后，血糖值出现最大值1-2小时。注射后1-2天内恢复正常。大约15%的注射剂量被排出。注射剂量约为5IU/kg的粗鳗鱼胰岛素在注射后2-3天可引起低血糖，高剂量的牛胰岛素也可引起类似的缓慢降糖反应。尽管这些发现表明胰岛素可以控制粘液的血糖水平，但在空腹或强迫喂食的情况下，胰岛素没有引起任何高血糖，而去岛的鳗鱼的葡萄糖负荷曲线在葡萄糖负荷正常鳗的范围内。切除垂体后(观察3周内)未见持续的低血糖或高血糖反应，也未见胰岛的任何显微镜改变，而只是由于下丘脑区机械损伤引起的一过性血糖值升高。持续约18小时的一过性高血糖反应。也是在非特异性注射后获得的，例如过滤后的海水和蒸馏水。注射肾上腺素[肾上腺素]、牛胶Agon、甲状腺素、猪促肾上腺皮质激素、牛促甲状腺激素和含有生长激素的绵羊催乳素后，血糖水平在任何情况下都不会高于非特异性反应的血糖水平，尽管有一些形态学迹象表明哺乳动物激素对七鳃鳗有效。
No decrease in blood glucose levels was found to occur in fasting Myxine glutinosa over a 3-week period. After glucose loading at 8 oC the blood glucose values showed a maximum 1-2 hr. after the injection and a return to normal within 1-2 days. About 15% of the injected dose was excreted. Crude hagfish insulin at an approximate dose of 5 IU/kg evoked hypoglycemia 2-3 days after the injection and a similar slow hypoglycemic response was also obtained after high doses of ox insulin. In spite of these findings, indicating that insulin may control Myxine blood sugar levels, isletec-tomy did not evoke any hyperglycemia in fasting or force-fed hagfish, and the glucose-loading curve of isletectomized hagfish fell within the range of that of glucose-loaded normal hagfish. Hypophysectomy did not cause any lasting hypo- or hyperglycemic response (in 3 weeks of observation time), nor any microscopical changes in the islets, but only a transient rise in the blood glucose values which was ascribed to the mechanical trauma of the hypothalamic region. A transient hyperglycemic reaction lasting for about 18 hr. was also obtained after nonspecific injections, such as filtered sea water and distilled water. The blood glucose levels after administration of adrenalin [epinephrine], ox glue agon, thyroxine, pig corticotropin, ox thyrotropin, and sheep prolactin containing growth hormone did not in any case rise above that of the nonspecific reaction in spite of some morphological signs of the efficacy of the mammalian hormones in the hagfish.