Synthesis and self‐assembling behaviors of biotinylated pluronic/poly(lactic acid) biocompatible block copolymers in aqueous solutions
Synthesis and self‐assembling behaviors of biotinylated pluronic/poly(lactic acid) biocompatible block copolymers in aqueous solutions
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生物素化普朗尼克/聚乳酸生物相容性嵌段共聚物的合成及其在水溶液中的自组装行为
DOI：
10.1002/app.31125
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发表时间：
2010
影响因子：
3
通讯作者：
Jiayin Xie
中科院分区：
文献类型：
--
作者：
Zi;X. Xiong;Y. P. Li;Y. Gong;Xinghui Gui;Xi Ou;H. Lin;L. Zhu;Jiayin Xie
通过两步反应合成了4种生物素化Pluronic/PLA嵌段共聚物。首先用生物素对Pluronic进行修饰，得到B-Pluronic-OH。以L-丙交酯为单体，Biotin-Pluronic-OH为引发剂，辛酸亚锡（Sn（Oct）2）为催化剂，通过开环聚合制备了Biotin-Pluronic-PLA嵌段共聚物。采用荧光光谱、动态光散射（DLS）和透射电子显微镜（TEM）技术研究了生物素-聚乳酸（PLA）嵌段共聚物在水溶液中的自组装行为。生物素-F127-PLA-61、生物素-F87-PLA和生物素-P85-PLA纳米粒的粒径分别为198、229和257 nm，并且发现它们的形态为球形胶束。生物素-F127-PLA-87产生球形胶束和尺寸为127和906 nm的大复合胶束。利用人卵巢癌细胞OVCAR-3进行的细胞毒性研究表明，生物素-Pluronic-PLA嵌段共聚物具有良好的生物相容性。© 2009 Wiley Periodicals，Inc.应用聚合物科学杂志，2010年
Four kinds of Biotinylated Pluronic/PLA block copolymers were synthesized by two-step reactions. Pluronic were firstly modified by biotin to obtain B-Pluronic-OH. Biotin-Pluronic-PLA block copolymers were then produced by ring-opening polymerization of the monomer L-lactide using Biotin-Pluronic-OH as the initiator and stannous octoate (Sn(Oct)2) as the catalyst. The self-assembling behaviors of Biotin-Pluronic-PLA block copolymers in aqueous solutions were examined by fluorescence measurement, dynamic light scattering (DLS), and transmission electron microscopic (TEM) techniques. The size of Biotin-F127-PLA-61, Biotin-F87-PLA, and Biotin-P85-PLA nanoparticles were determined to be 198, 229, and 257 nm, respectively, and their morphologies were found to be spherical micelles. Biotin-F127-PLA-87 produces both spherical micelles and large compound micelles with the size of 127 and 906 nm. The cytotoxicity studies using human ovarian cancer cells OVCAR-3 indicate that Biotin-Pluronic-PLA block copolymers have good biocompatibility. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
影响因子：
3.8
作者：
Cannizzaro, SM;Padera, RF;Shakesheff, KM
通讯作者：
Shakesheff, KM