Enhanced tryptophan degradation in patients with ovarian carcinoma correlates with several serum soluble immune activation markers
Enhanced tryptophan degradation in patients with ovarian carcinoma correlates with several serum soluble immune activation markers
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DOI：
10.1016/j.imbio.2010.07.010
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发表时间：
2011-03-01
期刊：
影响因子：
2.8
通讯作者：
Fuchs, Dietmar
中科院分区：
文献类型：
--
作者：
Sperner-Unterweger, Barbara;Neurauter, Gabriele;Fuchs, Dietmar
色氨酸降解酶吲哚胺2，3-双加氧酶（IDO）代表了抗微生物和抗肿瘤免疫效应机制，但IDO也抑制T细胞应答，因此可能导致免疫系统衰竭。因此。IDO被认为是肿瘤细胞的一种免疫逃逸机制，与健康对照组相比，20例卵巢癌患者血液中色氨酸降解加速，这反映在犬尿氨酸与色氨酸的比值（kyn/trp）增加，这可以估计IDO活性。较高的FIGO分期而非肿瘤分级与较高的色氨酸降解率相关。Kyn/trp与细胞因子IL-6、可溶性白细胞介素-2受体-α和75 kDa INF-α受体以及巨噬细胞标记物新蝶呤的浓度密切相关（所有p
Tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) represents an antimicrobial and anti-tumoral immune effector mechanism, but IDO also suppresses T-cell responses and thus can cause immune system failure. Therefore. IDO was proposed as an immunoescape mechanism of tumor cells.Compared to healthy controls, accelerated tryptophan degradation was observed in the blood of 20 patients with ovarian carcinoma as is reflected by an increased kynurenine to tryptophan ratio (kyn/trp) which allows an estimate of IDO activity. Higher FIGO stage but not tumor grading was associated with a higher rate of tryptophan degradation. Kyn/trp correlated strongly with concentrations of cytokine IL-6, of soluble interleukin-2 receptor-alpha and 75 kDa INF-alpha receptor and of the macrophage marker neopterin (all p