Alteration of 8-hydroxyguanosine concentrations in the cerebrospinal fluid and serum from patients with Parkinson's disease
Alteration of 8-hydroxyguanosine concentrations in the cerebrospinal fluid and serum from patients with Parkinson's disease
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DOI：
10.1016/s0304-3940(02)01259-4
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发表时间：
2003-01-16
影响因子：
2.5
通讯作者：
Tohgi, H
中科院分区：
文献类型：
--
作者：
Abe, T;Isobe, C;Tohgi, H
为了探讨氧化性RNA损伤在帕金森病（PD）发病机制中的可能作用，测定了PD患者和对照组脑脊液（CSF）和血清中氧化应激标志物8-羟基鸟苷（8-OHG）的浓度。PD患者脑脊液中8-OHG浓度约为对照组的3倍（P < 0.001）。CSF中8-OHG浓度随病程延长而显著降低（r（s）=-0.46，P < 0.05）。然而，8-OHG在血清中的浓度没有显着改变PD患者相比，在对照组。此外，正常人和PD患者脑脊液中8-OHG浓度与血清中8-OHG浓度无相关性，提示脑脊液中8-OHG浓度不能反映血清中8-OHG浓度，而可能反映脑组织中8-OHG浓度。这些体内研究结果表明，在PD发展的早期阶段，8-OHG和增加的氧化性RNA损伤可能发挥作用。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
In order to investigate the possible role of oxidative RNA damage in the pathogenesis of Parkinson's disease (PD), the concentrations of the oxidative stress marker 8-hydroxyguanosine (8-OHG) were measured in the cerebrospinal fluid (CSF) and the serum of patients with PD and control subjects. The concentration of 8-OHG in CSF in PD patients was approximately three-fold that in controls (P < 0.001). The concentration of 8-OHG in CSF decreased significantly with the duration of disease (r(s) = -0.46, P < 0.05). However, the concentration of 8-OHG in serum was not significantly altered in PD patients compared to that in controls. In addition, the concentration of 8-OHG in CSF showed no correlation with that in serum in both the controls and PD patients suggesting that the 8-OHG concentrations in the CSF do not reflect those in serum and may be probably reflect those in brain tissue. These in vivo findings suggest a possible role of 8-OHG and increased oxidative RNA damage in the early stage of the development of PD. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.