Flow Electrochemical Cyclizations via Amidyl Radicals: Easy Access to Cyclic Ureas
Flow Electrochemical Cyclizations via Amidyl Radicals: Easy Access to Cyclic Ureas
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DOI：
10.1055/s-0037-1611772
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发表时间：
2019-01-01
期刊：
影响因子：
2.5
通讯作者：
Vgenopoulou, Aggeliki
中科院分区：
文献类型：
--
作者：
Ahmed, Nisar;Vgenopoulou, Aggeliki
流动化学相对于间歇式工艺具有优势，可以在安全的工作条件下实现物质的高产率合成。电化学和流动微反应器技术的结合使化学转化成为可能，无需使用氧化剂或催化剂。在此，我们报道了通过 N-烯丙基脲的氧胺化来流式电合成环状脲。我们发现连续流能够优于间歇式，以优异的产率生产环状脲。
Flow chemistry has advantages over batch processes and can achieve the synthesis of substances in high yield under safe working conditions. The combination of electrochemistry and flow microreactor technology has made chemical transformations possible without the use of oxidants or catalysts. Herein, we report flow electrosynthesis of cyclic ureas via oxyamination of N-allylic ureas. We have found that continuous flow is able to outperform its batch counterpart, producing cyclic ureas in excellent yields.