Preferred retinal locus profile during prolonged fixation attempts
Preferred retinal locus profile during prolonged fixation attempts
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DOI：
10.1016/j.jcjo.2013.05.022
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发表时间：
2013-10-01
影响因子：
4.2
通讯作者：
Amoaku, Winfried M.
中科院分区：
文献类型：
--
作者：
Morales, Marco Ulises;Saker, Saker;Amoaku, Winfried M.
目的：在任何固定尝试中使用的视网膜区域或位置定义首选视网膜位点（PRL）。据推测，在长时间的固定尝试中，在PRL区域内可能存在各种具有代表性的参考点。本研究旨在澄清这一假设。设计：前瞻性、非随机、观察性病例系列。参与者：来自诺丁汉大学皇后医学中心视网膜和低视力诊所的41名患者的65只眼睛。方法：使用Macular Integrity Assessment （MAIA）显微测量设备（CenterVue, Padova, Italy）对来自英国诺丁汉大学皇后医学中心视网膜与低视力诊所的41例患者65只眼进行PRL评估。MAIA允许自动计算2个点，称为初始PRL (FRU)，在固定的前10秒后计算，以及最终PRL (PRLf)，在显微镜测试期间完成所有固定尝试后计算。结果：对所有患者的PRLi和PRLf进行了估计。46只（71%）眼固定稳定；46只眼中有40只（87%）的prl位于中央凹上方。65只眼中有19只（29%）被归类为不稳定或相对不稳定的固定；19只眼中有18只（95%）出现不同的PRLi和PRLf位置，其中13只（68%）出现干性老年性黄斑变性继发的中枢性地理萎缩。PRLi和PRLf的平均变化率为每单位距离变化5.3个固定单位。结论：在不同的固定阶段，延长固定时间的代表性穴位可能有所不同。这反映在患者的固定稳定性特征上，并可能与导致低视力的主要病理有关。
Objective: The retinal area or location used during any fixation attempt defines the preferred retinal locus (PRL). It is presumed that during prolonged fixation attempts there may be various representative reference points within the PRL area. This study aims to clarify this presumption.Design: Prospective, nonrandomized, observational case series.Participants: Sixty-five eyes of 41 patients from the University of Nottingham, Queen's Medical Centre Retina and Low Vision Clinics.Methods: A total of 65 eyes of 41 patients from the University of Nottingham, Queen's Medical Centre Retina and Low Vision Clinics were assessed for PRL using the Macular Integrity Assessment (MAIA) microperimetry equipment (CenterVue, Padova, Italy). The MAIA allows automatic calculation for 2 points named PRL initial (FRU), which is calculated after the first 10 seconds of fixation, and PRL final (PRLf), which is calculated after the completion of all fixation attempts during the microperimetry test.Results: Estimates of PRLi and PRLf were produced for all patients. Forty-six (71%) eyes were classified as having stable fixation; 40 of the 46 eyes (87%) had both PRLs location over the fovea centralis. Nineteen of 65 eyes (29%) were classified as having unstable or relatively unstable fixation; different PRLi and PRLf locations were found in 18 (95%) of the 19 eyes, including 13 (68%) with central geographic atrophy secondary to dry age-related macular degeneration. The mean rate of change was 5.3 units in fixation per unit change in distance in both PRLi and PRLf.Conclusions: The representative points during prolonged fixation attempts may vary at different stages of fixation. This is reflected in the characteristics of fixation stability of the patients and presents a possible association with main pathology responsible for low vision.