Reactive oxygen species and nitric oxide in cutaneous leishmaniasis.
Reactive oxygen species and nitric oxide in cutaneous leishmaniasis.
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DOI：
10.1155/2012/203818
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发表时间：
2012-01-01
影响因子：
2.2
通讯作者：
Vieira, Leda Quercia
中科院分区：
文献类型：
--
作者：
Horta, Maria Fatima;Mendes, Barbara Pinheiro;Vieira, Leda Quercia
皮肤利什曼病影响着全世界数百万人。几种利什曼原虫感染小鼠品系，小鼠模型密切复制人体寄生虫引起的皮肤病变。小鼠模型使研究宿主对感染抵抗力的发病机制和效应机制成为可能。本文综述了一氧化氮（NO）、活性氧（ROS）和过氧亚硝酸盐（ONOO（-））在巨噬细胞控制寄生虫中的作用。巨噬细胞既是宿主细胞，又是效应细胞。我们还讨论了利什曼原虫感染过程中嗜利什曼原虫衍生的氧和氮反应物种的作用。我们强调这些细胞在感染后早期，适应性T（h）细胞免疫反应之前，在利什曼病结局中的作用。
Cutaneous leishmaniasis affects millions of people around the world. Several species of Leishmania infect mouse strains, and murine models closely reproduce the cutaneous lesions caused by the parasite in humans. Mouse models have enabled studies on the pathogenesis and effector mechanisms of host resistance to infection. Here, we review the role of nitric oxide (NO), reactive oxygen species (ROS), and peroxynitrite (ONOO(-)) in the control of parasites by macrophages, which are both the host cells and the effector cells. We also discuss the role of neutrophil-derived oxygen and nitrogen reactive species during infection with Leishmania. We emphasize the role of these cells in the outcome of leishmaniasis early after infection, before the adaptive T(h)-cell immune response.