Right parietal hypoactivation in a cocaine-dependent group during a verbal working memory task
Right parietal hypoactivation in a cocaine-dependent group during a verbal working memory task
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DOI：
10.1016/j.brainres.2010.12.042
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发表时间：
2011-02-23
期刊：
影响因子：
2.9
通讯作者：
Avila, Cesar
中科院分区：
文献类型：
--
作者：
Bustamante, Juan-Carlos;Barros-Loscertales, Alfonso;Avila, Cesar
有人认为，可卡因成瘾会影响额顶叶网络参与执行功能，如注意力和工作记忆。因此，我们的目标是调查可卡因依赖的主题和健康对照组之间的大脑差异，在一个口头工作记忆任务的性能。19名对照男性和19名可卡因依赖男性进行了2-back任务。在1.5-T Siemens Avanto上采集数据。使用SPM 5进行图像处理和统计分析;使用生物参数映射（BPM）进行进一步的形态测量和相关性分析。两组之间未发现性能差异。然而，右下顶叶皮层（BA 40）的背侧部分在可卡因依赖组中激活较少。与对照组相比，痴呆症患者的任何大脑区域都没有过度活跃。我们的研究结果表明，可卡因依赖男性在执行口头工作记忆任务时，与注意力系统相关的大脑区域的激活减少。长期使用可卡因可能会影响右顶叶的注意力系统，使患者更容易出现注意力缺陷。(C)2010 Elsevier B. V.保留所有权利。
It has been suggested that cocaine addiction affects the engagement of the frontoparietal networks in executive functions, such as attention and working memory. Thus, our objective was to investigate brain differences between cocaine-dependent subjects and healthy controls during the performance of a verbal working memory task. Nineteen comparison men and nineteen cocaine-dependent men performed a 2-back task. Data were acquired on a 1.5-T Siemens Avanto. Image processing and statistical analyses were carried out using SPM5; Biological Parametric Mapping (BPM) was used for further morphometric and correlation analyses. No performance differences were found between groups. However, the dorsal part of the right inferior parietal cortex (BA 40) was less activated in the cocaine-dependent group. Cocaine patients did not overactive any brain area when compared with controls. Our results show reduced activation in the brain areas related to the attention system in cocaine-dependent men while performing a verbal working memory task. Chronic cocaine use may affect the attentional system in the right parietal lobe, making patients more prone to attentional deficits. (C) 2010 Elsevier B.V. All rights reserved.