The risk of cerebral damage during graded brain retractor pressure in the rat.
The risk of cerebral damage during graded brain retractor pressure in the rat.
复制标题
大鼠分级脑牵开器压力期间脑损伤的风险。
作者：
J. Rosenørn;N. Diemer
在30 mm Hg的压力下进行脑收缩，已证明局部脑血流量显著减少。作者进行了一项神经病理学研究，以评估在不同压力下应用脑牵开器15分钟对脑组织的影响。发现了以下变化：20 mm Hg的脑牵开器压力（BRP）后，6只动物中只有1只显示涉及所有皮质层的梗死; 30 mm Hg的BRP后，6只动物中有5只发现皮质梗死，部分出血; 40 mm Hg的BRP后，所有6只动物均显示皮质损伤。在牵开器应用区域外或更深的脑结构中没有脑损伤的迹象。得出的结论是，只有当BRP在15分钟内不超过20 mm Hg时，该模型才能避免损坏。
A considerable reduction in regional cerebral blood flow has been demonstrated with brain retraction at a pressure of 30 mm Hg. The authors undertook a neuropathological study to assess the effect on brain tissue of brain retractors applied at varying pressures for 15 minutes. The following changes were found: after 20 mm Hg of brain retractor pressure (BRP) only one of six brains revealed infarction involving all cortical layers; after 30 mm Hg of BRP cortical infarction, partly hemorrhagic, was found in five of six brains; after 40 mm Hg of BRP all six animals showed cortical damage. There were no signs of cerebral damage outside the retractor application area or in deeper brain structures. It was concluded that only if BRP did not exceed 20 mm Hg for 15 minutes could damage be avoided in this model.
影响因子：
4.1
作者：
JONES, TH;MORAWETZ, RB;OJEMANN, RG
通讯作者：
OJEMANN, RG