EFFECT OF 3'-5'-CYCLIC GMP DERIVATIVES ON FORMATION OF CAULOBACTER SURFACE-STRUCTURES
EFFECT OF 3'-5'-CYCLIC GMP DERIVATIVES ON FORMATION OF CAULOBACTER SURFACE-STRUCTURES
复制标题
DOI：
10.1073/pnas.73.9.3303
复制
发表时间：
1976-01-01
影响因子：
11.1
通讯作者：
SHAPIRO, L
中科院分区：
文献类型：
--
作者：
KURN, N;SHAPIRO, L
环[c]GMP的外源性衍生物8-溴-和N2，O2“-二丁酰cGMP协同抑制C. crescentus。在cGMP衍生物存在下的生长导致鞭毛和皮利形成的丧失以及伴随的对DNA噬菌体v φ CbK和RNA噬菌体v φ Cb 5感染的抗性，而不影响生长速率、茎形成和赤道细胞分裂。cGMP衍生物的作用是抑制特定结构蛋白的合成。这种效应可以被外源性N6，O2“-二丁酰cAMP逆转，并且对cGMP衍生物阻遏具有抗性的突变体表现出影响cAMP介导的事件的多效性表型。
Exogenous derivatives of cyclic [c]GMP, 8-bromo- and N2,O2''-dibutyryl cGMP, coordinately repress surface structure differentiation in C. crescentus. Growth in the presence of cGMP derivatives resulted in the loss of flagella and pili formation and concomitant resistance to DNA phage .vphi.CbK and RNA phage .vphi.Cb5 infection without affecting growth rate, stalk formation and equatorial cell division. The effect of cGMP derivatives was the repression of synthesis of specific structural proteins. This effect may be reversed by exogenous N6,O2''-dibutyryl cAMP, and mutants resistant to repression by cGMP derivatives exhibited a pleiotropic phenotype affecting a cAMP-mediated event.