High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing γδ T cells.
High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing γδ T cells.
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DOI：
10.1038/s41598-017-14292-1
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发表时间：
2017-10-26
影响因子：
4.6
通讯作者：
Kabashima K
中科院分区：
文献类型：
--
作者：
Nakamizo S;Honda T;Adachi A;Nagatake T;Kunisawa J;Kitoh A;Otsuka A;Dainichi T;Nomura T;Ginhoux F;Ikuta K;Egawa G;Kabashima K
银屑病是一种常见的慢性炎症性皮肤病，其特征是通过IL-23/IL-17轴表皮增生。各种研究表明肥胖和牛皮癣之间存在关联，然而，潜在的机制尚不清楚。为此，我们在本研究中重点关注高脂肪饮食（HFD），因为高脂肪饮食被认为是肥胖的一个因素，而喂食高脂肪饮食的小鼠表现出加重的银屑病皮炎。利用咪喹莫特（IMQ）诱导的银屑病小鼠模型和hfd诱导的肥胖模型，我们揭示了hfd诱导银屑病皮炎加重的新机制。饲喂hfd的小鼠银屑病性皮炎加重，皮肤中产生il - 17a的v - γ4+ γδ T细胞积累增加。HFD还诱导皮肤引流淋巴结等其他器官中v - γ - 4+ γδ T细胞的增加，其增加先于皮肤中v - γ - 4+ γδ T细胞的增加。此外，饲喂hfd的小鼠皮肤中几种γδ T细胞募集趋化因子的表达增加。另一方面，ob/ob小鼠，正常饮食的另一种小鼠肥胖模型，没有表现出加重的银屑病皮炎，也没有真皮中γδ T细胞的积累。这些结果表明，HFD是imq诱导的银屑病皮炎加重的关键因素，并进一步提高了HFD作为肥胖和银屑病之间联系因素的可能性。
Psoriasis is a common, chronic inflammatory skin disease characterized by epidermal hyperplasia via the IL-23/IL-17 axis. Various studies have indicated the association between obesity and psoriasis, however, the underlying mechanisms remains unclarified. To this end, we focused on high-fat diet (HFD) in this study, because HFD is suggested as a contributor to obesity, and HFD-fed mice exhibit exacerbated psoriatic dermatitis. Using murine imiquimod (IMQ)-induced psoriasis and HFD-induced obesity models, we have revealed a novel mechanism of HFD-induced exacerbation of psoriatic dermatitis. HFD-fed mice exhibited aggravated psoriatic dermatitis, which was accompanied with increased accumulation of IL-17A-producing Vγ4+ γδ T cells in the skin. HFD also induced the increase of Vγ4+ γδ T cells in other organs such as skin draining lymph nodes, which preceded the increase of them in the skin. In addition, HFD-fed mice displayed increased expression of several γδ T cell-recruiting chemokines in the skin. On the other hand, ob/ob mice, another model of murine obesity on normal diet, did not exhibit aggravated psoriatic dermatitis nor accumulation of γδ T cells in the dermis. These results indicate that HFD is a key element in exacerbation of IMQ-induced psoriatic dermatitis, and further raise the possibility of HFD as a factor that links obesity and psoriasis.
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影响因子：
6.5
作者：
Mabuchi, Tomotaka;Singh, Tej Pratap;Takekoshi, Tomonori;Jia, Guang-fu;Wu, Xuesong;Kao, Mandy C.;Weiss, Ido;Farber, Joshua M.;Hwang, Sam T.
通讯作者：
Hwang, Sam T.
影响因子：
82.9
作者：
通讯作者：
--
DOI：
10.1084/jem.190.12.1755
发表时间：
1999-12-20
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Charbonnier AS;Kohrgruber N;Kriehuber E;Stingl G;Rot A;Maurer D
通讯作者：
Maurer D
DOI：
10.1016/j.bbrc.2004.08.024
发表时间：
2004-09-24
影响因子：
3.1
作者：
Shimamura, M;Matsuda, M;Shimomura, L
通讯作者：
Shimomura, L
影响因子：
6.5
作者：
Chiricozzi, Andrea;Guttman-Yassky, Emma;Krueger, James G.
通讯作者：
Krueger, James G.