SEROTONIN - SYNTHESIS AND RELEASE FROM MYENTERIC PLEXUS OF MOUSE INTESTINE
SEROTONIN - SYNTHESIS AND RELEASE FROM MYENTERIC PLEXUS OF MOUSE INTESTINE
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DOI：
10.1126/science.149.3680.197
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发表时间：
1965-01-01
期刊：
影响因子：
56.9
通讯作者：
ROSS, LL
中科院分区：
文献类型：
--
作者：
GERSHON, MD;DRAKONTI.AB;ROSS, LL
在注射其放射性前体5-羟色氨酸后，放射性5-羟色胺被生物合成并结合在小鼠肠的肌间神经丛中。将非放射性5-羟色胺添加到体外制剂中会导致放射性5-羟色胺从神经丛中净释放。这种释放似乎是肠壁内神经系统活动的结果。蠕动反射通路中感觉神经元和运动神经元之间的神经递质作用被认为是解释5-羟色胺作用的一个工作假说。
After injection of its radioactive precursor, 5-hydroxytryptophan, radioactive serotonin was biosynthesized and bound in the myenteric plexus of the mouse intestine. Addition of nonradioactive serotonin to preparations in vitro caused a net release of radioactive serotonin from the plexus. This release appeared to result from activity in the intramural nervous system of the intestine. A neurotransmitter role between sensory and motor neurons in the peristaltic reflex pathway is suggested as a working hypothesis to explain the action of serotonin.