The effect of cholecystokinin‐related peptides on periodic pancreatic secretion in fasting dogs.
The effect of cholecystokinin‐related peptides on periodic pancreatic secretion in fasting dogs.
复制标题
胆囊收缩素相关肽对禁食犬周期性胰腺分泌的影响。
DOI：
10.1113/jphysiol.1988.sp017235
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
S. Naruse
中科院分区：
文献类型：
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作者：
D. F. Magee;S. Naruse
1.在禁食清醒犬中研究了八肽胆囊收缩素（CCK-8）和五肽胃泌素对胰腺周期性分泌的影响。2.小剂量的CCK-8和五肽胃泌素都延长了周期性胰腺分泌的间隔。周期性被大剂量的CCK-8和五肽胃泌素破坏。3.在不破坏周期的剂量下，CCK-8升高了一个周期中蛋白分泌的峰和谷-谷平均值，但不升高谷平均值。除了在大剂量下，五肽胃泌素未能增加峰值和谷平均值，但增加了平均值，谷到谷蛋白分泌。大剂量的五肽胃泌素和CCK-8都增加了谷蛋白的分泌。4.周期性胰腺蛋白分泌的峰值约为观察到的对CCK-8的最大蛋白反应的一半。5.阿托品降低了对小剂量CCK-8的胰腺液和蛋白质反应至谷水平。然而，在大剂量下，阿托品增强了这两种反应。六烃季铵可将对任何剂量CCK-8的反应降低至谷值水平或更低。阿托品或六烃季铵后对五肽胃泌素的体积和蛋白质反应与谷值水平相似。6.可以得出结论，CCK-8和五肽胃泌素通过作用于腺泡细胞直接刺激胰腺酶分泌，并通过改变控制清醒犬周期性分泌的胆碱能神经节活动间接刺激胰腺酶分泌。
1. The effect of cholecystokinin octapeptide (CCK‐8) and pentagastrin on periodic pancreatic secretion was studied in fasting conscious dogs. 2. Both CCK‐8 and pentagastrin, in small doses, prolonged the interval of periodic pancreatic secretion. Periodicity was disrupted by large doses of CCK‐8 and pentagastrin. 3. CCK‐8, at the dose which did not disrupt the cycle, raised the peak and the valley‐to‐valley means, but not the valley mean, of protein secretion in one cycle. Except at large doses, pentagastrin failed to increase the peak and valley mean, but increased mean, valley‐to‐valley protein secretion. Large doses of both pentagastrin and CCK‐8 increased protein secretion at the valley. 4. The peak of periodic pancreatic protein secretion was about half the observed maximum protein response to CCK‐8. 5. Atropine reduced pancreatic fluid and protein responses to small doses of CCK‐8 to the levels of valleys. At large doses, however, both responses were augmented by atropine. Hexamethonium reduced the responses to any dose of CCK‐8 to valley levels or less. Volume and protein responses to pentagastrin following atropine or hexamethonium were of similar magnitude to those at valleys. 6. It is concluded that CCK‐8 and pentagastrin stimulate pancreatic enzyme secretion directly by acting on acinar cells and indirectly by modifying cholinergic ganglionic activities which control periodic secretion in conscious dogs.