The common marmoset as suitable nonhuman alternative for the analysis of primate cochlear development.
The common marmoset as suitable nonhuman alternative for the analysis of primate cochlear development.
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DOI：
10.1111/febs.15341
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Ogawa K
中科院分区：
文献类型：
--
作者：
Hosoya M;Fujioka M;Murayama AY;Okano H;Ogawa K
耳蜗发育是一个复杂的过程，具有精确的时空模式。对这一过程的详细了解对先天性耳聋和再生医学的研究非常重要。然而，我们对耳蜗发育的大部分理解都是基于啮齿动物模型。需要在人类和啮齿动物之间架起桥梁的动物模型。在这项研究中，我们研究了一种小的新大陆猴子物种--常见的绒猴(Callithrix Is Jacchus)的听力器官的发育。我们描述了耳蜗发育的一般阶段，并与人类和小鼠的阶段进行了比较。此外，我们还研究了超过25种与耳蜗发育有关的蛋白质，发现它们在啮齿动物和灵长类动物中的表达模式通常是保守的。然而，参与支持细胞过程和神经元发育的几种蛋白质表现出种间表达差异。用于研究灵长类特定耳蜗发育的人类胎儿样本极其罕见，尤其是在发育后期阶段。我们的结果支持使用普通的绒猴作为灵长类耳蜗动物发育分析的有效替代。我们研究了一种小的新大陆猴子物种--常见的绒猴(Callithrix The Jacchus)的耳蜗发育。我们发现，参与耳蜗发育的蛋白质在啮齿动物和灵长类动物中的表达模式通常是保守的。然而，参与支持细胞过程和神经元发育的几种蛋白质表现出种间表达差异。我们的结果支持使用普通的绒猴作为灵长类耳蜗动物发育分析的有效替代。
Cochlear development is a complex process with precise spatiotemporal patterns. A detailed understanding of this process is important for studies of congenital hearing loss and regenerative medicine. However, much of our understanding of cochlear development is based on rodent models. Animal models that bridge the gap between humans and rodents are needed. In this study, we investigated the development of hearing organs in a small New World monkey species, the common marmoset (Callithrix jacchus). We describe the general stages of cochlear development in comparison with those of humans and mice. Moreover, we examined more than 25 proteins involved in cochlear development and found that expression patterns were generally conserved between rodents and primates. However, several proteins involved in supporting cell processes and neuronal development exhibited interspecific expression differences. Human fetal samples for studies of primate‐specific cochlear development are extremely rare, especially for late developmental stages. Our results support the use of the common marmoset as an effective alternative for analyses of primate cochlear development. We investigated cochlear development in a small New World monkey species, the common marmoset (Callithrix jacchus). We found that expression patterns of the proteins involved in cochlear development were generally conserved between rodents and primates. However, several proteins involved in supporting cell processes and neuronal development exhibited interspecific expression differences. Our results support the use of the common marmoset as an effective alternative for analyses of primate cochlear development.
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DOI：
10.1242/dev.029330
发表时间：
2008-12
期刊：
Development (Cambridge, England)
影响因子：
--
作者：
Abraira VE;Del Rio T;Tucker AF;Slonimsky J;Keirnes HL;Goodrich LV
通讯作者：
Goodrich LV
影响因子：
3.6
作者：
Eckhard, Andreas;Gleiser, Corinna;Hirt, Bernhard
通讯作者：
Hirt, Bernhard
影响因子：
3.2
作者：
Crouch, JJ;Sakaguchi, N;Schulte, BA
通讯作者：
Schulte, BA
DOI：
10.1002/ar.21298
发表时间：
2011-02-01
影响因子：
2
作者：
Armstrong, Stephanie D.;Bloch, Jonathan I.;Silcox, Mary T.
通讯作者：
Silcox, Mary T.
影响因子：
16.6
作者：
Defourny, Jean;Poirrier, Anne-Lise;Malgrange, Brigitte
通讯作者：
Malgrange, Brigitte