EVIDENCE THAT MATERNAL DENGUE ANTIBODIES ARE IMPORTANT IN THE DEVELOPMENT OF DENGUE HEMORRHAGIC-FEVER IN INFANTS
EVIDENCE THAT MATERNAL DENGUE ANTIBODIES ARE IMPORTANT IN THE DEVELOPMENT OF DENGUE HEMORRHAGIC-FEVER IN INFANTS
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DOI：
10.4269/ajtmh.1988.38.411
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发表时间：
1988-03-01
影响因子：
3.3
通讯作者：
BURKE, DS
中科院分区：
文献类型：
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作者：
KLIKS, SC;NIMMANITYA, S;BURKE, DS
为确定母体登革热特异性抗体在婴儿感染登革2型病毒引发登革出血热和登革休克综合征过程中的作用，我们检测了患有登革出血热或登革休克综合征的婴幼儿的母亲以及不明原因发热婴儿的母亲的血清。针对登革2型病毒的血凝抑制、中和及感染增强活性的平均滴度在三组之间无统计学差异。然而，在患登革出血热/登革休克综合征的婴儿中，母亲的登革2型中和抗体滴度与婴儿患重症时的年龄之间存在很强的相关性，而在其他两组中未发现这种相关性。此外，每个婴儿发生登革出血热/登革休克综合征的实际年龄与预测单核吞噬细胞对登革2型感染的最大增强活性的年龄相关。观察到登革出血热/登革休克综合征发生的关键时间大约是母体登革2型中和抗体降至保护水平以下所计算时间之后的2个月。此外，患有登革出血热/登革休克综合征的婴儿的母亲的血清对登革2型病毒感染的增强程度略高于不明原因发热婴儿的母亲以及患有登革出血热/登革休克综合征的幼儿的母亲的血清。这些数据与以下假说相符：母体登革抗体起着双重作用，首先对感染登革2型病毒的婴儿起到保护作用，随后增加其患登革出血热/登革休克综合征的风险。
To establish the role of maternal dengue-specific antibodies in the development of dengue hemorrhagic fever and dengue shock syndrome caused by dengue 2 virus in infants, we examined sera from mothers of infants and toddlers with dengue hemorrhagic fever of dengue shock syndrome and mothers of infants with pyrexia of unkonwn origin . The mean titers of hemagglutination inhibition, neutralization, and infection-enhancing activities against dengue 2 virus were not statistically different among the three groups. However, among infants who developed dengue homorrhagic fever/dengue shock syndrome there was a strong correlation between the mothers'' dengue 2 neutralizing titers and infant age at the time of onset of severe illness, where no such correlation was found among the other two groups.Furhermore, the actual age at which dengue hemorrhagic fever/dengue shock syndrome occurred in each infant correlated with the age at which maximum enhancing activity for dengue 2 infection in mononuclear phagocytes was predicted. This critical time for the occurrence of dengue hemorrhagic fever/dengue shock syndrome was observed to be approximately 2 months after the time calculated for maternal dengue 2 neutralizing antibodies to degrade below a protective level. In addition, sera of mothers of infants with dengue hemorrhagic fever/dengue shock syndrome enhanced dengue 2 virus infection to a slightly greater degree than did sera from mothers of infants with pyrexia of unknown origin and toddlers with dengue hemorrhagic fever/dengue shock syndrome. These data are consistent with the hypothesis that maternal dengue antibodies play a dual role by first protecting and later increasing the risk of development of dengue hemorrhagic fever/dengue shock syndrome in infants who become infected by dengue 2 virus.