Tmeff2 is expressed in differentiating oligodendrocytes but dispensable for their differentiation in vivo.
Tmeff2 is expressed in differentiating oligodendrocytes but dispensable for their differentiation in vivo.
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Tmeff2 在分化的少突胶质细胞中表达，但对于其在体内的分化来说是可有可无的
DOI：
10.1038/s41598-017-00407-1
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发表时间：
2017-03-23
影响因子：
4.6
通讯作者：
Qiu M
中科院分区：
文献类型：
--
作者：
Huang H;Teng P;Mei R;Yang A;Zhang Z;Zhao X;Qiu M
Myelin elaborated by oligodendrocytes (OLs) in the central nervous system (CNS) is required for saltatory conduction of action potentials along neuronal axons. We found that TMEFF2, a transmembrane protein with EGF-like and two follistatin-like domains, is selectively expressed in differentiating/myelinating OLs. Previous studies showed that TMEFF2 is capable of binding to PDGFA, which plays important roles in the proliferation, migration and differentiation of oligodendrocyte progenitor cells (OPCs). However, molecular and genetic analysis revealed that Tmeff2 is a weak binder of PDGFA, and not required for OL differentiation and myelin gene expression in vivo. Together, our data suggested that Tmeff2 is specifically upregulated in OLs, but dispensable for OL differentiation and maturation.
