The influence of high-altitude living on body iron
The influence of high-altitude living on body iron
复制标题
DOI：
10.1182/blood-2004-12-4782
复制
发表时间：
2005-08-15
期刊：
影响因子：
20.3
通讯作者：
Daroca, MD
中科院分区：
文献类型：
--
作者：
Cook, JD;Boy, E;Daroca, MD
基于血清铁蛋白和转铁蛋白受体测量的体铁定量评估被用来检查800名玻利维亚母亲和他们的一个小于5岁的孩子的铁状况。调查包括生活在海拔156至3750米之间的人口。母亲体内铁储存量平均为3.88 +/- 4.31 mg/kg（平均值+/- 1 SD），儿童为1.72 +/- 4.53 mg/kg。在儿童中没有检测到海拔高度对体内铁的一致影响，但生活在3000米以上的妇女体内铁储存量为2.77 +/- 0.70 mg/kg（平均值+/- 2标准误[SE]），与生活在低海拔的妇女相比减少了三分之一（P < .001）。不到2岁的儿童中有一半缺铁，但铁储备随后线性增加，到4岁时接近母亲的值。当母亲的身体铁与他们的孩子相比，一个显着的相关性被观察到在整个频谱的母亲铁状态（r = 0.61，P <0.001）。这一发现可以提供迄今为止最有力的证据，证明膳食铁作为弱势群体铁状况的决定因素的重要性。
The quantitative assessment of body iron based on measurements of the serum ferritin and transferrin receptor was used to examine iron status in 800 Bolivian mothers and one of their children younger than 5 years. The survey included populations living at altitudes between 156 to 3750 m. Body iron stores in the mothers averaged 3.88 +/- 4.31 mg/kg (mean +/- 1 SD) and 1.72 +/- 4.53 mg/kg in children. No consistent effect of altitude on body iron was detected in children but body iron stores of 2.77 +/- 0.70 mg/kg (mean +/- 2 standard error [SE]) in women living above 3000 m was reduced by one-third compared with women living at lower altitudes (P < .001). One half of the children younger than 2 years were iron deficient, but iron stores then increased linearly to approach values in their mothers by 4 years of age. When body iron in mothers was compared with that of their children, a striking correlation was observed over the entire spectrum of maternal iron status (r = 0.61, P < .001). This finding could provide the strongest evidence to date of the importance of dietary iron as a determinant of iron status in vulnerable segments of a population.