Competition for glucose between Candida albicans and oral bacteria grown in mixed culture in a chemostat
Competition for glucose between Candida albicans and oral bacteria grown in mixed culture in a chemostat
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DOI：
10.1099/0022-1317-49-11-969
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发表时间：
2000-11-01
影响因子：
3
通讯作者：
Basson, NJ
中科院分区：
文献类型：
--
作者：
Basson, NJ
研究了白色念珠菌与口腔混合菌群对葡萄糖作为生长限制底物的竞争。恒化器在葡萄糖限制和葡萄糖过量条件下以0.05/h的稀释速率操作。建立口腔细菌的混合种群，在达到稳定状态后，用C.白色念珠菌7种细菌包括血链球菌、S. sobrinus，S.缓症杆菌、干酪乳杆菌、Veillonella dispar、Saburreum真杆菌和具核梭杆菌-能够在葡萄糖限制条件下建立稳定的种群。在葡萄糖限制下，酵母不能与细菌一起生长。只有三个细菌物种，S，sobrinus，L，酪蛋白酸E，saburreum，成为葡萄糖过量条件下建立。白色念珠菌也能够在葡萄糖过量恒化器中建立，并且可以在与这些生物体的混合培养物中生长并保持稳定状态。干酪乳杆菌、缓症乳杆菌和远缘乳杆菌的葡萄糖消耗速率比梭菌快。白色念珠菌。除F. nucleatum的最大比生长速率高于C.结果提示，葡萄糖可能是白色念珠菌的生长限制底物。白念珠菌在口腔中建立和生长的酵母菌混合菌群。
The competition for glucose as a growth-limiting substrate between Candida albicans and a mixed community of oral bacteria was investigated. A chemostat was operated under glucose-limiting and glucose excess conditions at a dilution rate of 0.05/h. A mixed population of oral bacteria was established and after a steady state had been reached the chemostat was inoculated with C. albicans. Seven bacterial species Streptococcus sanguis, S. sobrinus, S. mitis, Lactobacillus casei, Veillonella dispar, Eubacterium saburreum and Fusobacterium nucleatum - were able to establish stable populations under glucose-limiting conditions. The yeast was unable to grow with the bacteria under glucose limitation. Only three bacterial species, S, sobrinus, L, casei acid E, saburreum, became established under glucose-excess conditions. C, albicans was also able to become established in the glucose-excess chemostat and could grow and maintain a steady state in a mixed culture with these organisms. L, casei, S, mitis and S, sobrinus had faster glucose consumption rates than C. albicans. All the bacteria, except for F. nucleatum, had maximum specific growth rates higher than C. albicans, The results suggest that glucose may act as a growth-limiting substrate for C. albicans in the establishment and growth of the yeast in a mixed community of oral bacteria.