Cerebrovascular reactivity and reserve capacity in type II diabetes mellitus
Cerebrovascular reactivity and reserve capacity in type II diabetes mellitus
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DOI：
10.1016/s1056-8727(99)00044-6
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发表时间：
1999-07-01
影响因子：
3
通讯作者：
Csiba, L
中科院分区：
文献类型：
--
作者：
Fülesdi, B;Limburg, M;Csiba, L
本研究的目的是检验非胰岛素依赖型糖尿病患者脑血管储备能力和脑血管反应性受损的假设。我们还打算研究可能影响静息脑血流速度和脑血管储备能力的因素。共28例患有II型糖尿病和20名健康对照者进行了研究。根据糖尿病病程将患者分为两组：病程> 10年和病程≤ 10年。分别于安静时和静注乙酰唑胺1g后测定大脑中动脉平均血流速度。计算脑血管反应性和储备能力。测定血糖、胰岛素、糖化血红蛋白、止血因子（纤维蛋白原、α 2巨球蛋白和血管性血友病因子抗原）。比较两个糖尿病亚组和对照组的脑血管反应性和储备能力值。采用线性回归分析探讨实验室参数与脑血管储备的相关性。对照组和两个糖尿病亚组的静息脑血流速度相似。病程> 10年的糖尿病患者脑血管反应性升高的时间短于对照组和短期糖尿病患者。长期糖尿病组的脑血管储备能力（平均值+/- SD：39.6 +/- 20.7%）低于病程小于或等于10年的患者（63.3 +/-17.4%，Bonferroni校正后p < 0.02）。脑血管储备能力与病程呈负相关（R = 0.53，p < 0.003）。所有实验室指标均与静息脑血流量和脑血管储备能力无关。长期存在的II型糖尿病患者脑小动脉的血管舒张能力减弱。（Journal of Diabetes and Its Complications 13;4：191-199，1999）(C)1999 Elsevier Science Inc.
The aim of the study was to test the hypothesis that cerebrovascular reserve capacity and cerebrovascular reactivity are impaired in patients suffering from non insulin-dependent diabetes mellitus. We also intended to investigate factors which may influence resting cerebral blood flow velocity and cerebrovascular reserve capacity. A total of 28 patients suffering from type II diabetes mellitus and 20 healthy control subjects were studied. Based on diabetes duration patients were divided into two groups: subjects with > 10 years and those with less than or equal to 10 years disease duration. Middle cerebral artery mean blood flow velocities were measured at rest and after intravenous administration of 1g acetazolamide. Cerebrovascular reactivity and reserve capacity were calculated. Blood glucose, insulin, glycosylated hemoglobin, hemostatic factors (fibrinogen, alpha-2 macroglobulin and von Willebrand factor antigen) were determined. Cerebrovascular reactivity and reserve capacity values were compared between the two diabetic subgroups and controls. Correlations between laboratory parameters and cerebrovascular reserve were investigated by linear regression analysis. Resting cerebral blood flow velocity was similar in controls and in the two diabetic subgroups. Cerebrovascular reactivity was elevated for a shorter time in patients with > 10 years disease duration than in controls and shortterm diabetic patients. Cerebrovascular reserve capacity was lower in the long-term diabetes group (means +/- SD: 39.6 +/- 20.7%) than in patients with less than or equal to 10 years disease duration (63.3 +/- 17.4%, p < 0.02 after Bonferroni correction). Cerebrovascular reserve capacity was inversely related to the duration of the disease (R = 0.53, p < 0.003). None of the determined laboratory factors had any relation with resting cerebral blood flow and cerebrovascular reserve capacity. The vasodilatory ability of cerebral arterioles is diminished in long-standing type II diabetes mellitus. (Journal of Diabetes and Its Complications 13;4:191-199, 1999.) (C) 1999 Elsevier Science Inc.