Mesenchymal Stem Cell-derived Extracellular Vesicles for Renal Repair.
Mesenchymal Stem Cell-derived Extracellular Vesicles for Renal Repair.
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DOI：
10.2174/1566523217666170412110724
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发表时间：
2017
影响因子：
3.6
通讯作者：
Eirin A
中科院分区：
文献类型：
--
作者：
Nargesi AA;Lerman LO;Eirin A
自体间充质干细胞（MSC）的移植已被证明可以减轻几种动物模型中的肾损伤和功能障碍，其疗效目前正在肾脏疾病患者的临床试验中进行测试。越来越多的证据表明，MSC释放细胞外囊泡（EV），将基因，microRNA和蛋白质递送到受体细胞，充当MSC旁分泌作用的介质。在这种情况下，关键是表征MSC衍生的EV货物，以阐明其对肾修复的潜在贡献。近年来，研究人员进行了高通量测序和蛋白质组学分析，以检测和鉴定MSC衍生EV中富集的基因、microRNA和蛋白质。本综述总结了目前对MSC衍生EV分泌组的了解，以阐明介导MSC肾修复的机制，并讨论了测试MSC衍生EV治疗肾脏疾病疗效的临床前和临床研究。
Transplantation of autologous mesenchymal stem cells (MSCs) has been shown to attenuate renal injury and dysfunction in several animal models, and its efficacy is currently being tested in clinical trials for patients with renal disease. Accumulating evidence indicates that MSCs release extracellular vesicles (EVs) that deliver genes, microRNAs and proteins to recipient cells, acting as mediators of MSC paracrine actions. In this context, it is critical to characterize the MSC-derived EV cargo to elucidate their potential contribution to renal repair. In recent years, researchers have performed high-throughput sequencing and proteomic analysis to detect and identify genes, microRNAs, and proteins enriched in MSC-derived EVs. The present review summarizes the current knowledge of the MSC-derived EV secretome to shed light into the mechanisms mediating MSC renal repair, and discusses preclinical and clinical studies testing the efficacy of MSC-derived EVs for treating renal disease.