Dietary antioxidant capacity and risk for stroke in a prospective cohort study of Swedish men and women
Dietary antioxidant capacity and risk for stroke in a prospective cohort study of Swedish men and women
复制标题
DOI：
10.1016/j.nut.2016.07.009
复制
发表时间：
2017-01-01
期刊：
影响因子：
4.4
通讯作者：
Bellocco, Rino
中科院分区：
文献类型：
--
作者：
Colarusso, Luca;Serafini, Mauro;Bellocco, Rino
目的：观察性研究和随机试验都表明，富含抗氧化剂的饮食可以减少全身性炎症和氧化应激，这两种情况与肥胖和吸烟一起是中风的危险因素。然而，人们对抗氧化剂摄入量与中风风险之间的关系知之甚少，特别是在研究与性别可能的相互作用时。我们在一个大型的瑞典前瞻性队列中研究了非酶抗氧化能力（NEAC）与卒中风险的关系。方法：队列研究包括来自瑞典国家三月队列的34555名男性和女性。使用基线时收集的详细食物频率问卷对NEAC进行评估。我们实现了从1997年到2010年通过记录链接到全国登记注册登记的完整随访。我们确定了1186例首次卒中病例，其中860例为缺血性，201例为出血性，125例未指明。结果：与NEAC最低四分位数的女性相比，NEAC最高四分位数的女性总卒中发生率低27（HR，0.73; 95% CI，0.53-0.99; P趋势= 0.03）和缺血性卒中发生率降低35%（HR，0.65; 95% CI，0.33 -0.99; P趋势= 0.01）。在男性中，NEAC和中风的风险之间的关系是没有统计学意义和所有的HR接近unity.Conclusion：从本研究的结果表明，从不同的食物和饮料的饮食抗氧化能力与中风的风险呈负相关，更具体的缺血性中风，在女性。(C)2016 Elsevier Inc. All rights reserved.
Objective: Both observational studies and randomized trials have shown that a diet rich in antioxidants can reduce systemic inflammation and oxidative stress, two conditions that, together with obesity and smoking, are established risk factors for stroke. However, the association between antioxidant intake and risk for stroke is poorly understood, particularly when studying possible interaction with sex. We investigated the relationship of nonenzymatic antioxidant capacity (NEAC) on risk for stroke in a large Swedish prospective cohortMethods: The cohort study included 34 555 men and women from the Swedish National March Cohort. NEAC was assessed using a detailed food frequency questionnaire, collected at baseline. We achieved complete follow-up from enrollment in 1997 through 2010 by record linkage to nationwide registers. We identified 1186 incident cases of a first stroke, of which 860 were ischemic, 201 hemorrhagic, and 125 unspecified. We used multivariable Cox proportional hazards models to estimate adjusted hazard ratios (HR) with 95% confidence intervals (CIs).Results: Compared with women in the lowest quartile of NEAC, women in the highest quartile had a 27% lower incidence of total stroke (HR, 0.73; 95% CI, 0.53-0.99; P-trend = 0.03) and 35% lower incidence of ischemic stroke (HR, 0.65; 95% CI, 0A3-0.99; P-trend = 0.01). Among men, the relationship between NEAC and risk for stroke was not statistically significant and all HRs were close to unity.Conclusion: Findings from the present study suggest that dietary antioxidant capacity from different foods and beverages is inversely associated with risk for stroke, more specifically ischemic stroke, in women. (C) 2016 Elsevier Inc. All rights reserved.