Photothermal therapy of Lewis lung carcinoma in mice using gold nanoshells on carboxylated polystyrene spheres
Photothermal therapy of Lewis lung carcinoma in mice using gold nanoshells on carboxylated polystyrene spheres
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DOI：
10.1088/0957-4484/19/45/455101
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发表时间：
2008-11-12
期刊：
影响因子：
3.5
通讯作者：
Li, Yi
中科院分区：
文献类型：
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作者：
Liu, Huiyu;Chen, Dong;Li, Yi
报道了一种在羧化聚苯乙烯小球(GNCPS)上设计金纳米壳层的新方法。采用种子生长法在羧化聚苯乙烯微球表面自组装了金纳米壳层。将壳聚糖(CHI)作为羧化聚苯乙烯微球的功能剂，将其应用于金种子的包埋。GNCPS的表面等离子体共振(SPR)峰可以在包括近红外(NIR)波长在内的广泛光谱范围内进行调谐，极大地红移，从而提供最大限度的光穿透组织。当GNCPS的消光系数达到峰值时，会将光能转换为热能，从而导致局部温度升高。我们的研究表明，小鼠Lewis肺癌(LLC)在低剂量(808 nm，4W cm(-2))的近红外光照射下发生了不可逆转的组织损伤。治疗组肿瘤体积明显小于对照组，平均抑瘤率达55%以上(P<；0.005)。本研究证明GNCPSS在等离子体光热治疗肿瘤方面具有广阔的应用前景。
A new approach towards the design of gold nanoshells on carboxylated polystyrene spheres (GNCPSs) is reported here. Gold nanoshells were self-assembled on the surface of carboxylated polystyrene spheres by a seed growth method. Chitosan (CHI) was used as a functional agent of carboxylated polystyrene spheres for attaching gold seeds. The surface plasmon resonance (SPR) peak of GNCPSs can be tuned, greatly redshifted, over a broad spectral range including the near-infrared (NIR) wavelength region, which provides maximal penetration of light through tissue. Irradiation of GNCPSs at their peak extinction coefficient results in the conversion of light to heat energy that produces a local rise in temperature. Our study revealed that the Lewis lung carcinoma (LLC) in mice treated with GNCPSs exposed to a low dose of NIR light (808 nm, 4 W cm(-2)) induced irreversible tissue damage. The tumor volumes of the treatment group by GNCPSs were significantly lower than those of control groups, with an average inhibition rate over 55% (P < 0.005). This study proves that GNCPSs are promising in plasmonic photothermal tumor therapy.