Glucose-6-Phosphate Dehydrogenase in the Pentose Phosphate Pathway Is Localized in Vanadocytes of the Vanadium-Rich Ascidian, Ascidia sydneiensis samea
Glucose-6-Phosphate Dehydrogenase in the Pentose Phosphate Pathway Is Localized in Vanadocytes of the Vanadium-Rich Ascidian, Ascidia sydneiensis samea
复制标题
磷酸戊糖途径中的葡萄糖 6 磷酸脱氢酶位于富钒海鞘 (Ascidia sydneiensis Samea) 的钒细胞中
作者：
T. Uyama;Kazuhiro Yamamoto;K. Kanamori;H. Michibata
摘要海鞘是一种固着的海洋动物，能选择性地在含钒血细胞（钒细胞）中积累大量的钒。几乎所有积累在钒细胞液泡中的钒都通过+4氧化态还原为+3氧化态，尽管钒在海水中以+5氧化态溶解。已经提出了一些参与还原的还原剂。通过化学研究，据报道，在NADPH存在下，+5氧化态的钒被还原为+4氧化态。本研究揭示了葡萄糖-6-磷酸脱氢酶（G6 PDH）的存在，第一个酶产生NADPH的戊糖磷酸途径，在钒丰富的海鞘的钒细胞。结果表明，G6 PDH结合了海鞘钒细胞中钒从+5氧化态到+4氧化态的还原。
Abstract Ascidians are sessile marine animals known to accumulate high levels of vanadium selectively in vanadium-containing blood cells (vanadocytes). Almost all the vanadium accumulated in the vacuoles of vanadocytes is reduced to the +3 oxidation state via the +4 oxidation state, although vanadium is dissolved in the +5 oxidation state in sea water. Some of the reducing agents that participate in the reduction have been proposed. By chemical study, vanadium in the +5 oxidation state was reported to be reduced to the +4 oxidation state in the presence of NADPH. The present study revealed the existence of glucose-6-phosphodehydrogenase (G6PDH), the first enzyme to produce NADPH in the pentose phosphate pathway, in vanadocytes of a vanadium-rich ascidian. The results suggested that G6PDH conjugates the reduction of vanadium from the +5 through to the +4 oxidation state in vanadocytes of ascidians.
影响因子：
3.9
作者：
Lee,S;Kustin,K;Robinson,WE;Frankel,RB;Spartalian,K
通讯作者：
Spartalian,K
海鞘中的钒和斑色素的化学。
影响因子：
--
作者：
Smith,MJ;Ryan,DE;Nakanishi,K;Frank,P;Hodgson,KO
通讯作者：
Hodgson,KO