Prediction error for free monetary reward in the human prefrontal cortex
Prediction error for free monetary reward in the human prefrontal cortex
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DOI：
10.1016/j.neuroimage.2004.07.028
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发表时间：
2004-11-01
期刊：
影响因子：
5.7
通讯作者：
Passinghm, RE
中科院分区：
文献类型：
--
作者：
Ramnani, N;Elliott, R;Passinghm, RE
预测未来奖励是灵长类动物的一项重要能力，其神经生理机制已被广泛研究。一种重要的方法是识别处理与奖励预测相关的错误的神经系统（即，记录不可预测奖励的发生和预期奖励的失败的区域）。在学会在奖励导向行为中预测食欲奖励的猴子中，多巴胺神经元可靠地发出两种预测错误的信号。人类大脑中涉及处理金钱奖励预测错误的机制还没有得到很好的理解。此外，当奖励不取决于行为时，这种系统是如何运作的，我们一无所知。我们使用事件相关的功能磁共振成像来定位对这两类预测错误的反应。受试者能够根据先前的视觉线索预测金钱奖励或非奖励。在偶尔的试验中，线索-结果的偶然性被颠倒了（不可预测的奖励和预期奖励的失败）。受试者不需要做出决定或行动。我们将每种类型的预测误差试验与相应的对照试验进行了比较，其中相同的预测没有失败。每种类型的预测误差都会诱发不同额颞回路的活动。意外的奖励失败引起了颞叶皮层和额极（第10区）的活动。不可预测的奖励诱发了眶额皮质、额极、海马旁皮质和小脑的活动。额颞回路中的活动时间锁定在预测错误上，这表明它们参与了人类大脑中视觉线索和金钱奖励之间的关联编码。(C)2004年爱思唯尔公司All rights reserved.
Making predictions about future rewards is an important ability for primates, and its neurophysiological mechanisms have been studied extensively. One important approach is to identify neural systems that process errors related to reward prediction (i.e., areas that register the occurrence of unpredicted rewards and the failure of expected rewards). In monkeys that have learned to predict appetitive rewards during reward-directed behaviors, dopamine neurons reliably signal both types of prediction error. The mechanisms in the human brain involved in processing prediction error for monetary rewards are not well understood. Furthermore, nothing is known of how such systems operate when rewards are not contingent on behavior. We used event-related fMRI to localize responses to both classes of prediction error. Subjects were able to predict a monetary reward or a nonreward on the basis of a prior visual cue. On occasional trials, cue-outcome contingencies were reversed (unpredicted rewards and failure of expected rewards). Subjects were not required to make decisions or actions. We compared each type of prediction error trial with its corresponding control trial in which the same prediction did not fail. Each type of prediction error evoked activity in a distinct frontotemporal circuit. Unexpected reward failure evoked activity in the temporal cortex and frontal pole (area 10). Unpredicted rewards evoked activity in the orbitofrontal cortex, the frontal pole, parahippocampal cortex, and cerebellum. Activity timelocked to prediction errors in frontotemporal circuits suggests that they are involved in encoding the associations between visual cues and monetary rewards in the human brain. (C) 2004 Elsevier Inc. All rights reserved.