Populations of wide-field amacrine cells in the mouse retina
Populations of wide-field amacrine cells in the mouse retina
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DOI：
10.1002/cne.21126
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发表时间：
2006-12-10
影响因子：
2.5
通讯作者：
Masland, Richard H.
中科院分区：
文献类型：
--
作者：
Bin Lin;Masland, Richard H.
我们使用一种转基因菌株的大量视网膜观察了小鼠的广域无长突细胞，转基因菌株在分离的视网膜细胞中表达绿色荧光蛋白(GFP)。广域细胞的多样性和数量令人惊讶。他们组成的群体可以由乔木深度、乔木大小和胞体大小来定义。按照常规标准，这些细胞群构成了11种无长突细胞“类型”。其他人在鼠标中报告了另外五种类型。大约三分之二的广野无长突细胞是轴突细胞，它们有独立的树突和轴突。单个细胞的轴突有时覆盖大部分视网膜表面。轴突细胞似乎是离心性传导神经元，类似于其他物种的电生理学研究。虽然它们被归类为独立的形态类型，但它们的生理功能似乎代表着单一组织计划的变化。这些细胞存在于内网状层的每一层，这表明它们影响到小鼠视网膜到大脑的最终输出的大部分，也就是说，影响到几乎所有的视觉功能。
We surveyed wide-field amacrine cells in the mouse, using a large series of retinas from a transgenic strain that expresses the green fluorescent protein (GFP) in isolated retinal cells. Wide-field cells were present in surprising diversity and number. They formed groups that could be defined by arbor depth, arbor size, and soma size. By conventional criteria, these populations of cells make up 11 amacrine cell "types." Five additional types have been reported by others in the mouse. Roughly two-thirds of the wide-field amacrine cells are axon-bearing cells, which have separate dendritic and axonal arbors. The axonal arbor of a single cell sometimes covers the majority of the retinal surface. The axon-bearing cells appear to be centrifugally conducting neurons similar to those studied electrophysiologically in some other species. Although they are classified as independent morphological types, it seems likely that their physiological functions represent variations on a single organizational plan. These cells are present at every level of the inner plexiform layer, which suggests that they affect most of the mouse retina's final outputs to the brain and, by implication, almost all visual function.