Stage distribution in patients with a small (≤ 3 cm) primary nonsmall cell lungs carcinoma -: Implication for lung carcinoma screening
Stage distribution in patients with a small (≤ 3 cm) primary nonsmall cell lungs carcinoma -: Implication for lung carcinoma screening
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DOI：
10.1002/1097-0142(20011215)92:12
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发表时间：
2001-12-15
期刊：
影响因子：
6.2
通讯作者：
Patz, EF
中科院分区：
文献类型：
--
作者：
Heyneman, LE;Herndon, JE;Patz, EF
背景最近，人们对使用计算机断层扫描（CT）进行肺癌筛查越来越感兴趣。为了使这种技术有效，小肿瘤必须在比大病变更早的阶段被检测到。然而，据作者所知，原发性小肿瘤（小于或等于3cm）的大小与疾病的关系，在介绍阶段从来没有明确的。目前的研究是为了确定是否较小的病变确实有一个较早的阶段分布相比，较大的肿瘤。杜克大学医学中心肿瘤登记处确定了620例患者（261例女性和359例男性，平均年龄67岁），这些患者在1980-1999年间经病理证实患有直径小于或等于3 cm的原发性非小细胞肺癌。手术、病理;回顾性分析影像学资料，以确定病变的大小和发病时的疾病分期。根据肿瘤大小确定每个阶段内肿瘤大小的分布和疾病阶段的分布。发生在TNM分期IIIB疾病患者中的肿瘤略大于在更晚期或不太晚期疾病患者中发现的肿瘤。然而，没有明显的统计学显着关系的阶段分布和大小的主要。lesion.CONCLUSIONS.目前的研究数据未发现小原发性肺肿瘤的大小与疾病分期分布之间存在统计学显著相关性。这一发现表明，使用筛查CT检测小肿瘤可能不会导致转移到早期疾病阶段分布。在开始大规模CT筛查计划之前，需要通过适当的临床试验证明死亡率的降低。(C)2001年美国癌症协会。
BACKGROUND. Recently, there has been increased interest in the use of computed tomography (CT) for lung carcinoma screening. For this technique to be effective, small tumors must be detected at an earlier stage than large lesions. However, to the authors's knowledge, the relationship between the size of small primary (less than or equal to 3 cm) neoplasms and disease, stage at presentation has never been established clearly. The current study was performed to determine whether smaller lesions indeed have an earlier stage distribution compared with larger tumors.METHODS. The Duke University Medical Center Tumor Registry identified 620 patients (261 women and 359 men, with a mean age of 67 years) who presented with pathologically proven primary nonsmall cell lung carcinomas measuring less than or equal to 3 cm between 1980-1999. Surgical, pathologic; and imaging information was reviewed retrospectively to confirm the size of the lesion and the disease stage at the time of presentation. The distribution of tumor size within each stage and the distribution of disease stage;according to tumor size were determined.RESULTS. Tumors occurring in patients with TNM Stage IIIB disease were slightly larger than those found in patients with either more advanced or less advanced disease. However, there was no apparent statistically significant relation between the stage distribution and the size of the primary. lesion.CONCLUSIONS. The current study data did not find a statistically significant relation between the size of small primary lung tumors and the distribution of disease stage at the time of presentation. This finding suggests that the detection of small tumors using screening CT may not result in a shift to an earlier disease stage distribution. A reduction in mortality needs to be demonstrated by appropriate clinical trials prior to the initiation of mass CT screening programs. (C) 2001 American Cancer Society.