The Microbiota in Inflammatory Bowel Disease in Different Age Groups (Retracted article. See vol. 32, pg. 312, 2014)
The Microbiota in Inflammatory Bowel Disease in Different Age Groups (Retracted article. See vol. 32, pg. 312, 2014)
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DOI：
10.1159/000228558
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发表时间：
2009-01-01
影响因子：
2.3
通讯作者：
Schippa, Serena
中科院分区：
文献类型：
--
作者：
Cucchiara, Salvatore;Iebba, Valerio;Schippa, Serena
背景资料：在过去的几十年中，人们做出了许多努力来评估肠道微生物群在炎症性肠病（IBD）中的作用，导致了一种假设，即除了特定病原体的存在之外，改变的微生物组成可能参与疾病的发病机制。另一方面，不同年龄组之间肠道微生物群落的现有差异使得IBD中微生物变化的研究越来越多。方法：采用培养、分子、代谢组学和宏基因组学等方法，对不同年龄段人群肠道菌群进行研究。结果和结论：在成人IBD中观察到厌氧菌（普通拟杆菌、粪链球菌）增加，而在儿科IBD中发现需氧菌和兼性厌氧菌（大肠杆菌）增加。在IBD中观察到总体上更高的细菌细胞计数，连同生物多样性的普遍丧失和拟杆菌门的优势以及厚壁菌门的平行减少：变形菌门的潜在有害成员的优势（E.大肠杆菌）和低丰度的有益物种（普氏粪杆菌）也分别报告在儿童和成人年龄组。老年人的微生物群落包含比儿童和成人更广泛的不同物种，无论是在健康还是IBD状态下。版权所有（C）2009 S. Karger AG，巴塞尔
Background: Many efforts were made in the past decades to assess the role of gut microbiota in inflammatory bowel diseases (IBD), leading to the hypothesis that an altered microbial composition, other than the presence of a specific pathogen, could be involved in the pathogenesis of the disease. On the other hand, existing differences in gut microbial community between distinct classes of age make sense of an increasing research in microbial shifts in IBD. Methods: Cultural, molecular, metabolomic and metagenomic approaches are trying to define the human gut microbiota in different age groups. Results and Conclusion: An increase in anaerobic bacteria (Bacteroides vulgatus, Streptococcus faecalis) was observed in adult IBD, whereas an increase in aerobic and facultative-anaerobic (Escherichia coli) was found in pediatric IBD. Overall higher bacterial cell counts were observed in IBD, jointly with a general loss of biodiversity and a preponderance of Bacteroidetes and a parallel decrease of Firmicutes phylum : a predominance of potential harmful members of Proteobacteria (E. coli) and low abundance of beneficial species (Faecalibacterium prausnitzii) was also reported in pediatric and adult age groups, respectively. Microbial community of elderly subjects contains a wider range of different species than those of children and adults, both in healthy and IBD status. Copyright (C) 2009 S. Karger AG, Basel