ISG15 in the tumorigenesis and treatment of cancer: An emerging role in malignancies of the digestive system.
ISG15 in the tumorigenesis and treatment of cancer: An emerging role in malignancies of the digestive system.
复制标题
ISG15 在肿瘤发生和癌症治疗中的作用：在消化系统恶性肿瘤中的新兴作用
DOI：
10.18632/oncotarget.11911
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发表时间：
2016-11-08
期刊：
影响因子：
--
通讯作者：
Ouyang L
中科院分区：
文献类型：
--
作者：
Zuo C;Sheng X;Ma M;Xia M;Ouyang L
干扰素刺激基因 15 泛素样修饰因子 (ISG15) 编码一种 IFN 诱导型泛素样蛋白。 ISG15 蛋白与多种细胞蛋白形成缀合物，这些蛋白参与多种细胞功能，包括干扰素诱导的免疫反应和细胞蛋白周转的调节。 ISG15 的表达和 ISG15 介导的缀合与多种人类肿瘤和癌细胞系有关，但 ISG15 在肿瘤发生和抗癌治疗反应中的作用仍然很大程度上未知。在这篇综述中，我们讨论了有关 ISG15 通路在消化系统癌症中的作用的最新研究结果。
The interferon-stimulated gene 15 ubiquitin-like modifier (ISG15) encodes an IFN-inducible, ubiquitin-like protein. The ISG15 protein forms conjugates with numerous cellular proteins that are involved in a multitude of cellular functions, including interferon-induced immune responses and the regulation of cellular protein turnover. The expression of ISG15 and ISG15-mediated conjugation has been implicated in a wide range of human tumors and cancer cell lines, but the roles of ISG15 in tumorigenesis and responses to anticancer treatments remain largely unknown. In this review, we discuss the findings of recent studies with regard to the role of ISG15 pathways in cancers of the digestive system.