Seroepidemiology of Campylobacter pyloridis.
Seroepidemiology of Campylobacter pyloridis.
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幽门弯曲杆菌的血清流行病学。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
D. Taylor
中科院分区：
文献类型：
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作者：
A. Morris;G. Nicholson;G. Lloyd;D. Haines;A. Rogers;D. Taylor
用酶联免疫吸附试验（ELISA）检测了1158份血清中的幽门弯曲菌IgG和伊加抗体。当用于检测胃镜检查患者血清时，该方法的敏感性为91%，特异性为75%。108例感染患者中有98例（91%）血清阳性，而92例未感染患者中只有23例（25%）血清阳性（p <0.001）。阳性血清学也与组织学胃炎相关（p <0.001）。当职业人群的血清相比，随机献血者血清，肉类工人，冷冻工程兽医和害虫控制人员有显着较高的血清阳性。库克群岛（33/85（39%））、萨摩亚（57/129（44%））和汤加（39/56（70%））献血者的血清阳性率也高于随机献血者（15/102（15%））（所有三个种族组的p均小于0.001）。血清阳性率随年龄增长而增加。结果表明，幽门螺杆菌感染是常见的某些群体在新西兰。这一发现的含义与幽门螺杆菌是病因相关的消化不良和消化性溃疡疾病的假设进行了讨论。
A total of 1158 sera were tested by an enzyme linked immunosorbent assay (ELISA) for IgG and IgA antibodies to Campylobacter pyloridis. When used to test sera from gastroendoscopy patients this method had a sensitivity of 91% and a specificity of 75%. Ninety-eight of 108 infected patients (91%) were seropositive whereas only 23 of 92 (25%) uninfected patients were seropositive (p less than 0.001). Positive serology was also associated with histological gastritis (p less than 0.001). When sera from occupational groups were compared to random blood donor sera, meat workers, freezing works veterinary surgeons and pest control officers had significantly higher seropositivity. Cook Island (33 of 85 (39%)), Samoan (57 of 129 (44%)) and Tongan (39 of 56 (70%)) blood donors also had greater seropositivity than random blood donors (15 of 102 (15%)), (p less than 0.001 for all three ethnic groups). Seropositivity increased with age. The results indicate that C pyloridis infection is common among certain groups within New Zealand. The implication of this finding with respect to the hypothesis that C pyloridis is aetiologically related to dyspepsia and peptic ulcer disease is discussed.