Platelet‐derived microparticles induce polymorphonuclear leukocyte‐mediated damage of human pulmonary microvascular endothelial cells
Platelet‐derived microparticles induce polymorphonuclear leukocyte‐mediated damage of human pulmonary microvascular endothelial cells
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DOI：
10.1111/trf.12952
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发表时间：
2015-05
期刊：
影响因子：
2.9
通讯作者：
R. Xie;P. Hu;Zhi Wang;Jie Yang;Yi Ming Yang;Li Gao;H. Fan;Yongming Zhu
中科院分区：
文献类型：
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作者：
R. Xie;P. Hu;Zhi Wang;Jie Yang;Yi Ming Yang;Li Gao;H. Fan;Yongming Zhu
储存在22°C下的血小板（PLT）积聚微粒和生物反应调节剂（BRM），其在输血接受者中诱导炎症反应。然而，可溶性BRM在接受者的血液循环中被完全稀释。BRM发挥其作用的机制尚未阐明。本研究的目的是确定PLT微粒（PMP）对多形核白细胞（PMN）介导的人肺微血管内皮细胞（HMVEC）损伤的影响，并确定可溶性CD40配体（sCD40 L）的作用。
Platelets (PLTs) stored at 22°C accumulate microparticles and biologic response modifiers (BRMs) that induce inflammatory reactions in transfusion recipients. However, soluble BRMs are fully diluted in the recipient's blood circulation. The mechanisms by which BRMs exert their effects have not been elucidated. The objectives of this study were to determine the effect of PLT microparticles (PMPs) on polymorphonuclear leukocyte (PMN)‐mediated human pulmonary microvascular endothelial cell (HMVEC) damage and determine the role of soluble CD40 ligand (sCD40L).