Trisomy for the smallest autosome of the mouse and identification of the T1Wh translocation chromosome.
Trisomy for the smallest autosome of the mouse and identification of the T1Wh translocation chromosome.
复制标题
小鼠最小常染色体的三体性和 T1Wh 易位染色体的鉴定。
DOI：
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发表时间：
1972
期刊：
影响因子：
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通讯作者：
C. Crandall
中科院分区：
文献类型：
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作者：
B. White;J. Tjio;L. Van De Water;C. Crandall
Quinacrine-mustard staining and Giemsa-banding identified the large chromosome of the T1Wh translocations as No. 5; the small autosome of the translocation had previously been found to be No. 19. Others have demonstrated that translocation T163H involved autosomes 9 and 19; these findings were confirmed in our study. Meiotic studies of (T1Wh × T163H) F1 hybrids showed a chain quadrivalent at metaphase I, confirming that both translocations shared in common only chromosome 19. Metaphase II analysis of F1 hybrids demonstrated frequent nondisjunction of the T1Wh and T163H translocation chromosomes, and 12 % of 75 F2 offspring from 16 F1 crosses were trisomic for chromosome 19. Trisomics had three translocation chromosomes and a chromosome number of 38. All newborn trisomics were smaller than their normal littermates and died during the first day of life. The only specific malformation found so far has been cleft palate.
