Murine leukemia virus-based Tat-inducible long terminal repeat replacement vectors: a new system for anti-human immunodeficiency virus gene therapy
Murine leukemia virus-based Tat-inducible long terminal repeat replacement vectors: a new system for anti-human immunodeficiency virus gene therapy
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DOI：
10.1128/jvi.70.11.8234-8240.1996
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发表时间：
1996-11
影响因子：
5.4
通讯作者：
Paula M. Cannon;Narry Kim;S. Kingsman;A. Kingsman
中科院分区：
文献类型：
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作者：
Paula M. Cannon;Narry Kim;S. Kingsman;A. Kingsman
我们已经构建了新的鼠白血病病毒（MLV）为基础的载体（TIN载体），整合后，含有人类免疫缺陷病毒（HIV）1型U3和R序列的MLV U3和R区的地方。这首次提供了在达特控制下的单个转录单位逆转录病毒载体。TIN载体对于抗HIV基因治疗应用具有几个优点。
We have constructed new murine leukemia virus (MLV)-based vectors (TIN vectors) which, following integration, contain human immunodeficiency virus (HIV) type 1 U3 and R sequences in place of the MLV U3 and R regions. This provides, for the first time, single transcriptional unit retroviral vectors under the control of Tat. TIN vectors have several advantages for anti-HIV gene therapy applications.