In vivo removal of malaria parasites from red blood cells without their destruction in acute falciparum malaria
In vivo removal of malaria parasites from red blood cells without their destruction in acute falciparum malaria
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DOI：
10.1182/blood.v90.5.2037
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发表时间：
1997-09-01
期刊：
影响因子：
20.3
通讯作者：
White, NJ
中科院分区：
文献类型：
--
作者：
Angus, BJ;Chotivanich, K;White, NJ
急性恶性疟感染时，含有丰富环状感染红细胞表面抗原的红细胞（Pf 155或RESA），但没有细胞内寄生虫，存在于循环中，这些RESA阳性寄生虫阴性RBC在体外寄生虫培养物中未见，这表明，在急性恶性疟中，体内宿主机制主动清除红细胞内寄生虫这可能解释了在一些高寄生虫血症患者中观察到的血细胞比容下降和寄生虫计数减少之间的差异，这些“一次寄生”RBC在体内的命运尚不清楚。(C)1997年，美国血液学会。
During acute falciparum malaria infection, red blood cells (RBC) containing abundant ring-infected erythrocyte surface antigen (Pf 155 or RESA), but no intracellular parasites, are present in the circulation, These RESA-positive parasite negative RBC are not seen in parasite cultures in vitro, This indicates that in acute falciparum malaria there is active removal of intraerythrocytic parasites by a host mechanism in vivo (probably the spleen) without destruction of the parasitized RBC, This may explain the observed disparity between the drop in hematocrit and decrease in parasite count in some hyperparasitemic patients, The fate of these ''once-parasitized'' RBC in vivo is not known. (C) 1997 by The American Society of Hematology.