Functional and Structural Neuroimaging Correlates of Repetitive Low-Level Blast Exposure in Career Breachers.
Functional and Structural Neuroimaging Correlates of Repetitive Low-Level Blast Exposure in Career Breachers.
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DOI：
10.1089/neu.2020.7141
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发表时间：
2020-12-01
影响因子：
4.2
通讯作者：
Ahlers ST
中科院分区：
文献类型：
--
作者：
Stone JR;Avants BB;Tustison NJ;Wassermann EM;Gill J;Polejaeva E;Dell KC;Carr W;Yarnell AM;LoPresti ML;Walker P;O'Brien M;Domeisen N;Quick A;Modica CM;Hughes JD;Haran FJ;Goforth C;Ahlers ST
战斗军事和民事执法人员在训练和行动期间可能会暴露在重复的低强度爆炸事件中。使用炸药进入（即闯入）建筑物的人被称为“闯入者”或动态进入人员。爆破手在既定安全规程的指导下作业，但尽管有这些预防措施，在整个职业生涯中暴露于低水平爆炸的爆破手经常向医疗保健提供者报告性能缺陷和症状。虽然我们对爆炸暴露与人类临床症状之间的病因学联系知之甚少，但动物研究表明，在反复爆炸暴露后，大脑功能发生了网络水平的变化，大脑形态发生了改变，血管和炎症发生了变化，听力下降，甚至基因表达发生了变化。为了探索类似的影响是否会发生在人类身上，我们收集了20名在职业生涯中暴露于爆炸的经验丰富的破坏者和14名军事和执法控制人员的综合数据。这一系列包括神经心理学评估、血液生物标志物和磁共振成像测量，包括皮质厚度、白质弥散张量成像、功能连通性和灌注。为了更好地理解重复低水平爆炸暴露与人类行为和成像差异之间的关系，我们使用相似性驱动的多视图线性重建（SiMLR）分析了数据。SiMLR是专门为使用降维技术进行多模态统计集成而设计的，用于高维但稀疏数据的研究（即，受试者数量少，每个受试者的数据多）。我们在这些跨越大脑结构、功能和血液生物标志物的数据中发现了显著的组效应。
Combat military and civilian law enforcement personnel may be exposed to repetitive low-intensity blast events during training and operations. Persons who use explosives to gain entry (i.e., breach) into buildings are known as “breachers” or dynamic entry personnel. Breachers operate under the guidance of established safety protocols, but despite these precautions, breachers who are exposed to low-level blast throughout their careers frequently report performance deficits and symptoms to healthcare providers. Although little is known about the etiology linking blast exposure to clinical symptoms in humans, animal studies demonstrate network-level changes in brain function, alterations in brain morphology, vascular and inflammatory changes, hearing loss, and even alterations in gene expression after repeated blast exposure. To explore whether similar effects occur in humans, we collected a comprehensive data battery from 20 experienced breachers exposed to blast throughout their careers and 14 military and law enforcement controls. This battery included neuropsychological assessments, blood biomarkers, and magnetic resonance imaging measures, including cortical thickness, diffusion tensor imaging of white matter, functional connectivity, and perfusion. To better understand the relationship between repetitive low-level blast exposure and behavioral and imaging differences in humans, we analyzed the data using similarity-driven multi-view linear reconstruction (SiMLR). SiMLR is specifically designed for multiple modality statistical integration using dimensionality-reduction techniques for studies with high-dimensional, yet sparse, data (i.e., low number of subjects and many data per subject). We identify significant group effects in these data spanning brain structure, function, and blood biomarkers.
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DOI：
10.1007/978-3-642-33454-2_26
发表时间：
2012
期刊：
LECTURE NOTES IN ARTIFICIAL INTELLIGENCE
影响因子：
--
作者：
Avants, Brian;Dhillon, Paramveer;Kandel, Benjamin M.;Cook, Philip A.;McMillan, Corey T.;Grossman, Murray;Gee, James C.
通讯作者：
Gee, James C.
影响因子：
5.7
作者：
Avants BB;Tustison NJ;Song G;Cook PA;Klein A;Gee JC
通讯作者：
Gee JC
影响因子：
5.7
作者：
Cook PA;McMillan CT;Avants BB;Peelle JE;Gee JC;Grossman M
通讯作者：
Grossman M
DOI：
10.1016/j.nicl.2016.12.017
发表时间：
2017
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Clark AL;Bangen KJ;Sorg SF;Schiehser DM;Evangelista ND;McKenna B;Liu TT;Delano-Wood L
通讯作者：
Delano-Wood L
影响因子：
5.7
作者：
Avants BB;Libon DJ;Rascovsky K;Boller A;McMillan CT;Massimo L;Coslett HB;Chatterjee A;Gross RG;Grossman M
通讯作者：
Grossman M