Association Between ABO Blood Group System and COVID-19 Susceptibility in Wuhan
Association Between ABO Blood Group System and COVID-19 Susceptibility in Wuhan
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DOI：
10.3389/fcimb.2020.00404
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发表时间：
2020-07-21
影响因子：
5.7
通讯作者：
Zhao, Fang
中科院分区：
文献类型：
--
作者：
Fan, Qian;Zhang, Wei;Zhao, Fang
背景：ABO血型系统与多种传染病有关，包括乙肝、登革出血热等。冠状病毒病2019(新冠肺炎)是一种新的呼吸道传染病，新冠肺炎与ABO血型系统的关系亟待探讨。方法：于2020年1月1日/2020年3月5日在武汉大学中南医院进行以医院为基础的病例对照研究。纳入新冠肺炎病例105例，对照103例。血型频率用卡方检验，并计算病例与对照组的优势比(OR)，其可信区间(CI)为95%。此外，根据性别，研究人群被分为两个亚组，我们按性别评估病例和对照之间的关联。最后，考虑到淋巴细胞减少是新冠肺炎的一个特征，在病例样本中确定了ABO血型与淋巴细胞计数的关系。结果：病例组A型、B型、AB型和O型血型频率分别为42.8%、26.7%、8.57%和21.9%。ABO血型与新冠肺炎的关联分析显示，A型血与新冠肺炎相关性有统计学意义(P=0.04，OR=1.33，95%CI=1.02~1.73)，而B型、AB型和O型差异无统计学意义(P=0.48，OR=0.90，95%CI=0.66~1.23；P=0.61，OR=0.88，95%CI=0.53~1.46；P=0.23，OR=0.82，95%CI=0.58~1.15)。按性别分层分析显示，A型血在女性亚组中的相关性非常显著(P=0.02，OR=1.56，95%CI=1.08~2.27)，而在男性亚组中则无统计学意义(P=0.51，OR=1.14，95%CI=0.78~1.67)。A型血患者的淋巴细胞计数平均水平最低，但与其他血型相比，仍无显著统计学差异。结论：我们的发现提供了流行病学证据，表明女性A型血对新冠肺炎易感。然而，这些研究结果还需要在未来的研究中得到验证。
Background:The ABO blood group system has been associated with multiple infectious diseases, including hepatitis B, dengue haemorrhagic fever and so on. Coronavirus disease 2019 (COVID-19) is a new respiratory infectious disease and the relationship between COVID-19 and ABO blood group system needs to be explored urgently. Methods:A hospital-based case-control study was conducted at Zhongnan Hospital of Wuhan University from 1 January 2020 to 5 March 2020. A total of 105 COVID-19 cases and 103 controls were included. The blood group frequency was tested with the chi-square statistic, and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated between cases and controls. In addition, according to gender, the studied population was divided into two subgroups, and we assessed the association between cases and controls by gender. Finally, considering lymphopenia as a feature of COVID-19, the relationship between the ABO blood group and the lymphocyte count was determined in case samples. Results:The frequencies of blood types A, B, AB, and O were 42.8, 26.7, 8.57, and 21.9%, respectively, in the case group. Association analysis between the ABO blood group and COVID-19 indicated that there was a statistically significant difference for blood type A (P= 0.04, OR = 1.33, 95% CI = 1.02-1.73) but not for blood types B, AB or O (P= 0.48, OR = 0.90, 95% CI = 0.66-1.23;P= 0.61, OR = 0.88, 95% CI = 0.53-1.46; andP= 0.23, OR = 0.82, 95% CI = 0.58-1.15, respectively). An analysis stratified by gender revealed that the association was highly significant between blood type A in the female subgroup (P= 0.02, OR = 1.56, 95% CI = 1.08-2.27) but not in the male subgroup (P= 0.51, OR = 1.14, 95% CI = 0.78-1.67). The average level of lymphocyte count was the lowest with blood type A in patients, however, compared with other blood types, there was still no significant statistical difference. Conclusions:Our findings provide epidemiological evidence that females with blood type A are susceptible to COVID-19. However, these research results need to be validated in future studies.