EFFECTS OF ANTIBIOTIC-TREATMENT OF NONLACTATING DAIRY-COWS ON ANTIBIOTIC-RESISTANCE PATTERNS OF BOVINE MASTITIS PATHOGENS
EFFECTS OF ANTIBIOTIC-TREATMENT OF NONLACTATING DAIRY-COWS ON ANTIBIOTIC-RESISTANCE PATTERNS OF BOVINE MASTITIS PATHOGENS
复制标题
DOI：
10.1128/aac.24.5.771
复制
发表时间：
1983-01-01
影响因子：
4.9
通讯作者：
DUNNY, GM
中科院分区：
文献类型：
--
作者：
BERGHASH, SR;DAVIDSON, JN;DUNNY, GM
主要的奶牛乳房炎病原菌群（无乳链球菌、其他链球菌、金黄色葡萄球菌和链球菌）的抗生素耐药性模式。通过测定13种不同抗生素对来自奶牛的细菌分离株的最小抑菌浓度（MIC）来检查表皮葡萄球菌（epidermidis）。从21个纽约州[美国]奶牛群调查的每头奶牛的牛奶样品中获得细菌菌株。在12个牛群调查（高剂量使用组）中，所有365头奶牛在每个泌乳周期结束时接受乳房抗生素输注。其他9个牛群调查中的324头动物（低抗生素使用组）在非哺乳期未常规接受抗生素。通过计算每个细菌组的平均MIC、抑制90%分离株所需的抗生素浓度和抑制50%分离株所需的抗生素浓度来比较来自2组的MIC。观察到沙门氏菌对所有13种抗生素的耐药性增加。从抗生素使用率高的畜群中分离出的无乳链球菌。在检查的其他细菌种属的耐药模式中，两组之间的差异相对较小。该研究最重要的发现是鉴定了多个β-内酰胺类耐药表型。无乳。
Antibiotic resistance patterns of the major groups of bovine mastitis pathogens (Streptococcus agalactiae, other streptococci, Staphylococcus aureus and S. epidermidis) were examined by determining the minimum inhibitory concentration (MIC) of the 13 different antibiotics against bacterial isolates from dairy cattle. The bacterial strains were obtained from milk samples from each cow in 21 New York state [USA] dairy herd surveys. In 12 herd surveys (high antibiotic-use group), all 365 cows received antibiotic infusions into the udder at the cessation of each lactation cycle. The 324 animals in the other 9 herd surveys (low antibiotic-use group) did not routinely receive antibiotics during the nonlactation period. The MIC from the 2 groups were compared by calculating for each bacterial group the average MIC, the antibiotic concentration necessary to inhibit 90% of the isolates and the antibiotic concentration necessary to inhibit 50% of the isolates. Increased resistance to all 13 antibiotics was observed with S. agalactiae isolates from the high antibiotic use herds. There was relatively little difference between the 2 groups in the resistance patterns of the other bacterial species examined. The most important finding of the study was the identification of a multiple .beta.-lactam resistance phenotype in S. agalactiae.