Interspecific hybrids show a reduced adaptive potential under DNA damaging conditions.
Interspecific hybrids show a reduced adaptive potential under DNA damaging conditions.
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DOI：
10.1111/eva.13155
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发表时间：
2021-03
影响因子：
4.1
通讯作者：
Landry CR
中科院分区：
文献类型：
--
作者：
Bautista C;Marsit S;Landry CR
杂交可以增加适应极端压力的可能性。这种优势可能是由于杂交后代基因组可塑性的增加，这可能会加速对适应性突变的搜索。高紫外线辐射在适应方面是一个特别的挑战，因为它通过直接破坏DNA影响生物体的生存能力，同时也通过增加突变率对后代构成挑战。在这里，我们测试是否杂交加速适应性进化的DNA损伤，使用酵母作为模型。我们将180个物种（酿酒酵母和奇异酵母）和它们的亲本菌株之间的杂交种群暴露于UV模拟和控制条件下约100代。虽然我们发现，适应发生在杂种和父母，杂种达到了较低的适应率，与我们的预期相反。适应DNA损伤条件对亲本和杂种来说都需要付出巨大且相似的成本，这表明这种成本并不是杂种适应性较低的原因。我们认为，在这种情况下，较低的适应能力的杂种可能是由于DNA损伤和杂种固有的遗传不稳定性之间的相互作用。
Hybridization may increase the probability of adaptation to extreme stresses. This advantage could be caused by an increased genome plasticity in hybrids, which could accelerate the search for adaptive mutations. High ultraviolet (UV) radiation is a particular challenge in terms of adaptation because it affects the viability of organisms by directly damaging DNA, while also challenging future generations by increasing mutation rate. Here we test whether hybridization accelerates adaptive evolution in response to DNA damage, using yeast as a model. We exposed 180 populations of hybrids between species (Saccharomyces cerevisiae and Saccharomyces paradoxus) and their parental strains to UV mimetic and control conditions for approximately 100 generations. Although we found that adaptation occurs in both hybrids and parents, hybrids achieved a lower rate of adaptation, contrary to our expectations. Adaptation to DNA damage conditions comes with a large and similar cost for parents and hybrids, suggesting that this cost is not responsible for the lower adaptability of hybrids. We suggest that the lower adaptive potential of hybrids in this condition may result from the interaction between DNA damage and the inherent genetic instability of hybrids.
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影响因子：
6.4
作者：
Adamo GM;Brocca S;Passolunghi S;Salvato B;Lotti M
通讯作者：
Lotti M
影响因子：
30.7
作者：
Becker, Matthias;Gruenheit, Nicole;Lockhart, Peter J.
通讯作者：
Lockhart, Peter J.
影响因子：
5
作者：
Bellon, Jennifer R.;Yang, Fei;Chambers, Paul J.
通讯作者：
Chambers, Paul J.
DOI：
10.1073/pnas.44.6.622
发表时间：
1958-01-01
影响因子：
11.1
作者：
DOBZHANSKY, T;PAVLOVSKY, O
通讯作者：
PAVLOVSKY, O
影响因子：
64.8
作者：
Cooper, VS;Lenski, RE
通讯作者：
Lenski, RE