The discovery of actin: "to see what everyone else has seen, and to think what nobody has thought"*
The discovery of actin: "to see what everyone else has seen, and to think what nobody has thought"*
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DOI：
10.1007/s10974-019-09515-z
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发表时间：
2020-03-01
影响因子：
2.7
通讯作者：
Kellermayer, Miklos
中科院分区：
文献类型：
--
作者：
Bugyi, Beata;Kellermayer, Miklos
肌动蛋白是真核细胞中含量最丰富、最普遍的蛋白质之一。在超过四分之三的世纪里，肌动蛋白的结构、动力学和功能多样性一直吸引着细胞和分子生物学家、生物学家和生理学家。肌动蛋白的发现和初步表征是由Ilona邦加和Bruno F.斯特劳布在第二次世界大战期间在匈牙利，是一个显着的和鼓舞人心的时刻，在科学史上。许多早期关于肌动蛋白，特别是肌动球蛋白的性质和功能的思想和观点，在这个简短的历史概述中提到，即使在今天也能引起新鲜的共鸣。
Actin is among the most highly abundant and ubiquitous proteins in eukaryotic cells. The structure, dynamics and functional diversity of actin have continued to mesmerise cell and molecular biologists, biophysicists and physiologists for more than three quarters of a century. The discovery and initial characterization of actin, which took place in the laboratory of Albert Szent-Gyorgyi by Ilona Banga and Bruno F. Straub during the second world war in Hungary, is a remarkable and inspiring moment in the history of science. Many of the early thoughts and ideas on the properties and functions of actin and particularly actomyosin, which are referred to in this short historical overview, resonate freshly even today.