SUBCLINICAL ABNORMALITIES OF GLUCOSE-METABOLISM IN SUBJECTS WITH PREVIOUS GESTATIONAL DIABETES
SUBCLINICAL ABNORMALITIES OF GLUCOSE-METABOLISM IN SUBJECTS WITH PREVIOUS GESTATIONAL DIABETES
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DOI：
10.1016/0002-9378(86)90155-9
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发表时间：
1986-12-01
影响因子：
9.8
通讯作者：
SIMS, EAH
中科院分区：
文献类型：
--
作者：
CATALANO, PM;BERNSTEIN, IM;SIMS, EAH
为探讨妊娠期糖尿病患者是否存在亚临床糖代谢异常，并与后期糖尿病的高发相一致，我们对8例妊娠期糖尿病患者进行了身体成分研究、静脉糖耐量试验、高胰岛素-正糖钳联合6-6二deuterated葡萄糖输注、间接量热法、以及胰岛细胞抗体的测定。8名对照受试者的体脂百分比和饮食习惯相匹配，并以类似的方式进行研究。4例（50%）既往妊娠期糖尿病患者存在胰岛素反应和胰岛素抵抗异常。患者的胰岛素抵抗明显高于对照组。与瘦患者相比，既往妊娠期糖尿病的肥胖患者对静脉葡萄糖耐量试验的胰岛素反应和胰岛素抵抗明显更高。这些变化与报道的妊娠糖尿病患者早期和进行性发展的显性糖尿病一致。
To investigate whether there are subclinical abnomalities of glucose metabolism in women with previous gestational diabetes that are consistent with a high incidence of diabetes mellitus in later life, eight patients with previous gestational diabetes and normal oral glucose tolerance were evaluated by means of body composition studies, intravenous glucose tolerance tests, and the hyperinsulinemic-euglycemic clamp coupled with 6-6 dideuterated glucose infusion, indirect calorimetry, and measurement of islet cell antibodies. Eight control subjects were matched for percent body fat and diet and studied in a similar fashion. Abnormalities of insulin response and insulin resistance were present in four (50%) of patients with previous gestational diabetes. Insulin resistance was significantly greater in the patients than in the control subjects. When compared with lean patients, obese patients with previous gestational diabetes had significantly greater insulin response to the intravenous glucose tolerance test and insulin resistance. These changes are consistent with reported findings of an early and progressive development of overt diabetes in patients who had gestational diabetes.