Dietary Iodine and Thyroid Cancer Risk in French Polynesia: A Case-Control Study
Dietary Iodine and Thyroid Cancer Risk in French Polynesia: A Case-Control Study
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DOI：
10.1089/thy.2011.0173
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发表时间：
2012-04-01
期刊：
影响因子：
6.6
通讯作者：
de Vathaire, Florent
中科院分区：
文献类型：
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作者：
Clero, Enora;Doyon, Francoise;de Vathaire, Florent
背景：法属波利尼西亚是世界上甲状腺癌发病率最高的地区之一。碘被怀疑在这种高发病率中发挥作用。本研究的目的是评估低碘饮食是否与甲状腺癌的高风险在法属波利尼西亚population.Methods：一个病例对照研究进行了法属波利尼西亚的本地居民。它包括1979年至2004年诊断的229例分化型甲状腺癌（203名女性，26名男性）与371名出生日期的对照人群（324名女性，47名男性）相匹配。目前的研究是集中在膳食碘摄入量和鱼类消费（富含碘的食物），并分析了条件logistic regression.Results：每日膳食碘摄入量不足（< 150微克/天），在60%的病例和对照组。甲状腺癌的风险随着鱼类（p（趋势）= 0.008）和贝类（p（趋势）= 0.002）的消费量增加而降低，并且随着膳食碘摄入量增加（p（趋势）= 0.03）而降低。甲状腺辐射剂量和膳食碘摄入量的影响之间没有显着的相互作用（p = 0.2）。结论：法属波利尼西亚是一个轻度缺碘地区，其中较高的消费量的食物从海和较高的膳食碘摄入量显着相关的甲状腺癌的风险降低。这种减少的量化需要对传统波利尼西亚食物中的碘摄入量进行具体调查。
Background: French Polynesia has one of the world's highest thyroid cancer incidence rates. Iodine is suspected to play a role in this high incidence. The objective of this study was to assess whether low dietary iodine is related to a higher risk of thyroid cancer in the French Polynesian population.Methods: A case-control study was performed among native residents of French Polynesia. It included 229 cases of differentiated thyroid cancer diagnosed between 1979 and 2004 (203 women, 26 men) matched with 371 population controls (324 women, 47 men) on the date of birth. The current study is focused on dietary iodine intake and fish consumption (food rich in iodine) and analyzed by conditional logistic regression.Results: Daily dietary iodine intake was insufficient (< 150 mu g/day) in 60% of both cases and controls. A decreased risk of thyroid cancer was observed with a higher consumption of fish (p(trend) = 0.008) and shellfish (p(trend) = 0.002), and also with a higher dietary iodine intake (p(trend) = 0.03). There was no significant interaction between the effects of the thyroid radiation dose and the dietary iodine intake (p = 0.2).Conclusion: French Polynesia is a mild iodine deficiency area in which a higher consumption of food from the sea and a higher dietary iodine intake are significantly associated with a decreased risk of thyroid cancer. The quantification of this reduction requires specific investigation of iodine intake in traditional Polynesian food.