Prognostic significance of tumor volume in patients with nasopharyngeal carcinoma undergoing intensity-modulated radiation therapy
Prognostic significance of tumor volume in patients with nasopharyngeal carcinoma undergoing intensity-modulated radiation therapy
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DOI：
10.1002/hed.23010
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发表时间：
2013-05-01
影响因子：
2.9
通讯作者：
Huang, Shao-Min
中科院分区：
文献类型：
--
作者：
Wu, Zheng;Zeng, Rui-Fang;Huang, Shao-Min
背景本研究旨在分析鼻咽癌调强放射治疗（IMRT）患者原发肿瘤体积（GTVp）与预后的关系。方法回顾性分析2001年2月至2006年12月间305例鼻咽癌调强放疗患者的临床资料。根据治疗计划CT扫描计算GTVp。结果单因素和多因素分析显示，GTVp与鼻咽癌的局部控制、远处转移和总生存率有显著相关性，而T分级不是独立的预后因素。在N01和N23分类的患者中，GTVp小于和大于25 mL的患者之间的远处转移率存在显著差异（分别为p <0.001和p = 0.002）。结论GTVp对评价鼻咽癌调强放疗的局部控制、远处转移和总生存率有重要意义。因此，建议将GTVp纳入新的TNM分类系统。(c)2012 Wiley Periodicals，Inc.头颈部，2013年
Background This study was undertaken to analyze the correlation between primary gross tumor volume (GTVp) and prognosis in patients with nasopharyngeal carcinoma (NPC) undergoing intensity-modulated radiation therapy (IMRT). Methods Between February 2001 and December 2006, 305 patients with NPC treated with IMRT were analyzed retrospectively. GTVp was calculated from treatment planning CT scans. Results Univariate and multivariate analyses indicated that GTVp had a statistically significant correlation to local control, distant metastasis, and overall survival in patients with NPC, whereas T classification was not an independent prognostic factor. Among patients classified with N01 and N23, there were significant differences in the rates of distant metastasis between those with GTVp smaller and larger than 25 mL (p < .001 and p = .002, respectively). Conclusions GTVp is highly significant in evaluating local control, distant metastasis, and overall survival of patients with NPC treated with IMRT. Therefore, it is recommended that GTVp be included in the new TNM classification system. (c) 2012 Wiley Periodicals, Inc. Head Neck, 2013