GROWTH-FACTORS AND CARCINOID-TUMORS
GROWTH-FACTORS AND CARCINOID-TUMORS
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DOI：
10.3109/02841869309083899
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发表时间：
1993-01-01
期刊：
影响因子：
3.1
通讯作者：
AHLMAN, H
中科院分区：
文献类型：
--
作者：
NILSSON, O;WANGBERG, B;AHLMAN, H
已经对人肠道类癌以及非洲鼹鼠胃类癌中生长因子及其受体的存在情况进行了研究。通过免疫细胞化学和放射免疫测定表明，人肠道类癌肿瘤产生胰岛素样生长因子 - I（IGF - I）。在一半的肿瘤中可检测到IGF - I受体，并且用IGF - I刺激培养的肿瘤细胞可增强DNA合成。因此，IGF - I可能作为类癌肿瘤生长的自分泌刺激因子。通过免疫细胞化学和Northern分析也可证实在肠道类癌中有转化生长因子 - α（TGF - α）和表皮生长因子受体（EGF - receptors）的表达，这表明TGF - α参与类癌生长的自分泌调节。人肠道类癌肿瘤与大鼠胎儿胆碱能神经元的共培养表明，培养的肿瘤细胞分泌一种有效的神经营养因子。IGF - I和TGF - α可能是这些神经营养作用的原因，但类癌肿瘤也可能分泌一种尚未确定的生长因子。在由于组胺H₂受体阻断导致高胃泌素血症期间，非洲鼹鼠的胃（ECL细胞）类癌迅速发展，这表明胃泌素是这些类癌的一种重要生长因子。
The presence of growth factors and their receptors in human midgut carcinoids and in gastric carcinoids of Mastomys have been investigated. Human midgut carcinoid tumours produce IGF-I as demonstrated by immunocytochemistry and radioimmunoassay. IGF-I receptors were detectable in half of the tumours and stimulation of cultured tumour cells with IGF-I enhanced DNA synthesis. IGF-I may therefore act as an autocrine stimulator of carcinoid tumour growth. Expression of TGF-alpha and EGF-receptors could also be demonstrated in midgut carcinoids by immunocytochemistry and Northern analysis, suggesting that TGF-alpha participates in the autocrine modulation of carcinoid growth. Co-culture of human midgut carcinoid tumours and rat fetal cholinergic neurons demonstrated secretion of a potent neuronotrophic factor by cultured tumour cells. IGF-I and TGF-alpha may account for these neuronotrophic effects, but carcinoid tumours may also secrete an as yet unidentified growth factor. Gastric (ECL cell) carcinoids developed rapidly in Mastomys during hypergastrinemia due to histamine2-receptor blockade, suggesting that gastrin is an essential growth factor for these carcinoids.