Molecular biology of rift valley Fever virus.
Molecular biology of rift valley Fever virus.
复制标题
DOI：
10.2174/1874357901004020008
复制
发表时间：
2010-04-22
期刊：
影响因子：
--
通讯作者：
Weber F
中科院分区：
文献类型：
--
作者：
Bouloy M;Weber F
裂谷热病毒（RVFV）在撒哈拉以南非洲和阿拉伯半岛的人类和家养动物中引起急性发热和经常致命的疾病的大爆发。RVFV是布尼亚病毒科、白蛉病毒属的成员。像这个大病毒家族的所有成员一样，它包含负/双义链RNA的三段基因组，包装成病毒核衣壳蛋白，并被含有两个病毒糖蛋白的脂质双层包裹。在过去的几年里，人们对RVFV的流行病学、分子生物学和毒力机制越来越感兴趣。在这里，我们将试图提供一个概述了这一重要病原体的基本特征，并回顾了这一高度活跃的研究领域的最新进展。
Rift Valley fever virus (RVFV) causes large outbreaks of acute febrile and often fatal illness among humans and domesticated animals in sub-saharan Africa and the Arabian peninsula. RVFV is a member of the family Bunyaviridae, genus Phlebovirus. Like all members of this large virus family, it contains a three-segmented genome of negative/ambisense strand RNA, packaged into viral nucleocapsid protein, and enveloped by a lipid bilayer containing two viral glycoproteins. During the past years, there was an increased interest in RVFV epidemiology, molecular biology, and virulence mechanisms. Here, we will try to provide an overview over the basic features of this significant pathogen, and review the latest developments in this highly active research field.