Neurogenic bladder in progressive supranuclear palsy: A comparison with Parkinson's disease and multiple system atrophy
Neurogenic bladder in progressive supranuclear palsy: A comparison with Parkinson's disease and multiple system atrophy
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DOI：
10.1002/nau.23496
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发表时间：
2018-06-01
影响因子：
2
通讯作者：
Kim, Jong-Min
中科院分区：
文献类型：
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作者：
Kim, Kyeong Joon;Jeong, Seong Jin;Kim, Jong-Min
目的进行性核上性麻痹（PSP）可出现泌尿系统症状，类似于其他帕金森病。方法回顾性分析20例以泌尿系统症状为主要表现的帕金森病（PSP）、帕金森病（IPD）和多系统萎缩（MSA）患者的尿动力学资料。临床数据，包括发病年龄，持续时间，和严重程度，以及帕金森病和泌尿系统症状的治疗状态被collected.ResultsA共131例（10与PSP，79与IPD，和42与MSA）。PSP患者的平均年龄和发病年龄与IPD患者相似，但高于MSA患者。PSP患者至出现泌尿系症状的病程与MSA相似，但短于IPD患者。尿动力学检查显示，PSP患者的储尿期功能障碍与IPD或MSA患者相似。然而，根据压力-流量研究，PSP患者表现出较高的排尿失败率，以及较低的最大流速，较高的排尿后残余容量，和较高比例的逼尿肌收缩受损比IPD患者，但相当相似的MSA patient.ConclusionsUrinary dysfunction在PSP患者的广泛与MSA，更严重的比那些与IPD，特别是在排尿阶段。这可能反映了PSP患者神经结构的广泛变性过程。
AimsProgressive supranuclear palsy (PSP) can present urinary symptoms, similar to other parkinsonian disorders. We investigated the urodynamic parameters of PSP and compared them with those of idiopathic Parkinson's disease (IPD) and multiple system atrophy (MSA)MethodsWe retrospectively analyzed the urodynamic data in patients diagnosed with parkinsonian disorders (PSP, IPD, and MSA) presenting urinary symptoms. Clinical data, including onset age, duration, and severity, as well as treatment status of parkinsonian disorders and urinary symptoms were collected.ResultsA total of 131 patients (10 with PSP, 79 with IPD, and 42 with MSA) were included. The mean age and disease onset age of PSP patients were similar to those of IPD patients, but older than those of MSA patients. The disease duration until the onset of urinary symptoms in PSP patients was similar to that in MSA patients, but shorter than that in IPD patients. According to the urodynamic study, storage phase dysfunctions in PSP patients were similar to those in IPD or MSA patients. However, according to a pressure-flow study, PSP patients showed higher rates of voiding failure, as well as lower maximum flow rate, higher post-void residual volume, and higher proportions of impaired detrusor contraction than IPD patients, but rather similar to MSA patients.ConclusionsUrinary dysfunctions in PSP patients were as extensive as those with MSA, and were more severe than those with IPD, especially in the voiding phase. This may reflect the extensive degenerative process of neural structure in PSP patients.