Elevated expression of USP9X correlates with poor prognosis in human non-small cell lung cancer
Elevated expression of USP9X correlates with poor prognosis in human non-small cell lung cancer
复制标题
USP9X 表达升高与人类非小细胞肺癌预后不良相关
DOI：
10.3978/j.issn.2072-1439.2015.04.28
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发表时间：
2015-04-01
影响因子：
2.5
通讯作者：
Xie, Cong-Hua
中科院分区：
文献类型：
--
作者：
Wang, You;Liu, Yu;Xie, Cong-Hua
背景资料：本研究的目的是调查泛素特异性肽酶9，X连锁（USP 9 X）在非小细胞肺癌（NSCLC）患者的表达，并评估USP 9 X表达与肿瘤预后的相关性。方法：2008年7月至2011年7月期间，95例接受手术切除的临床I-IIIA期NSCLC患者纳入本研究。对95例NSCLC组织和32例癌旁正常肺组织进行USP 9 X表达的免疫组化分析。采用卡方检验比较各组间的临床病理特征。Kaplan-Meier分析和考克斯回归模型用于确定独立的预后因素。结果：USP 9 X在NSCLC组织中的阳性表达率（44.2%）明显高于癌旁正常肺组织（6.3%）（P < 0.001）;在NSCLC患者中，USP 9 X高表达与淋巴结转移（P < 0.001）、临床分期（P < 0.001）和总生存率（P = 0.001）显著相关。多因素分析显示，USP 9 X蛋白的高表达是NSCLC患者预后不良的重要预测因子（HR = 2.244，P = 0.028）。结论：目前的研究表明，USP 9 X在NSCLC组织中的表达显著高于正常肺组织，并且这种升高的USP 9 X表达水平与NSCLC的不良预后相关这表明USP 9 X可能作为NSCLC的预后生物标志物。
Background: The aim of this study was to investigate the expression of ubiquitin-specific peptidase 9, X-linked (USP9X) in non-small cell lung cancer (NSCLC) patients and to evaluate the relevance of USP9X expression to tumor prognosis.Methods: Ninety-five patients who underwent surgical resection for clinical stage I-IIIA NSCLC between July 2008 and July 2011 were included in this study. Immunohistochemical analysis of USP9X expression was performed on 95 NSCLC tissues and 32 adjacent normal lung parenchymal tissues from these patients. The Chi-squared test was used to compare the clinicopathological characteristics between different groups. Kaplan-Meier analysis and a Cox regression model were used to determine the independent prognostic factors. A P value < 0.05 was considered to be significant.Results: The expression of USP9X was found to be significantly higher in NSCLC tissue (44.2%) than in adjacent normal lung parenchymal tissue (6.3%) (P < 0.001). High USP9X expression was significantly associated with positive lymph node metastasis (P < 0.001), clinical stage (P < 0.001) and a reduced overall survival rate (P = 0.001) in patients with NSCLC. Based on the multivariate analysis, the elevated expression of the USP9X protein was a significant predictor of poor prognosis for NSCLC patients (HR = 2.244, P = 0.028).Conclusions: The current study demonstrated that the expression of USP9X in NSCLC tissue was significantly higher than that in normal lung tissue and that this elevated expression level of USP9X was associated with poor prognosis among NSCLC patients, suggesting that USP9X might serve as a prognostic biomarker for NSCLC.