Comparison of circulating proinflammatory cytokines and soluble apoptosis mediators in patients with chronic heart failure with versus without symptoms of depression
Comparison of circulating proinflammatory cytokines and soluble apoptosis mediators in patients with chronic heart failure with versus without symptoms of depression
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DOI：
10.1016/j.amjcard.2004.07.127
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发表时间：
2004-11-15
影响因子：
2.8
通讯作者：
Kremastinos, DT
中科院分区：
文献类型：
--
作者：
Parissis, JT;Adamopoulos, S;Kremastinos, DT
这项临床研究比较了稳定的慢性心力衰竭和抑郁症状（根据 Zung 自评抑郁量表评估）患者 (n = 15) 和没有这些症状的患者 (n = 20) 之间循环促炎性（肿瘤坏死因子-α [TNFα] 和白细胞介素 6）和抗炎（白细胞介素 10）细胞因子和可溶性细胞凋亡介质（Fas/Fas 配体）的表达。与没有情绪困扰的患者相比，有抑郁症状的患者的 TNF-α 和可溶性 Fas 配体水平显着升高，而白细胞介素 10 水平显着降低。细胞因子网络失调和细胞凋亡信号分子激活可能与心力衰竭患者慢性情绪困扰和抑郁症状的病理生理学密切相关。 (C) 2004 年，Excerpta Medica, Inc.
This clinical study compared the expression of circulating proinflammatory (tumor necrosis factor-alpha [TNFalpha] and interleukin-6) and anti-inflammatory (interleukin-10) cytokines and soluble apoptosis mediators (Fas/Fas ligand) between patients with stable chronic heart failure and depressive symptoms (as estimated by the Zung Self-Rating Depression Scale) (n = 15) and those without these symptoms (n = 20). Patients with depressive symptoms exhibited significantly higher levels of TNF-alpha and soluble Fas ligand, as well as significantly lower levels of interleukin-10, than patients without emotional distress. A disregulated cytokine network and activated apoptosis signaling molecules may be actively implicated in the pathophysiology of chronic emotional distress and depressive symptoms inpatients with heart failure. (C) 2004 by Excerpta Medica, Inc.