Hypoxia-Inducible Factor-1α Target Genes Contribute to Retinal Neuroprotection.
Hypoxia-Inducible Factor-1α Target Genes Contribute to Retinal Neuroprotection.
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缺氧诱导因子 1 α 靶基因有助于视网膜神经保护
DOI：
10.3389/fncel.2017.00020
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发表时间：
2017
影响因子：
5.3
通讯作者：
Xiang M
中科院分区：
文献类型：
--
作者：
Cheng L;Yu H;Yan N;Lai K;Xiang M
缺氧诱导因子（Hypoxia-inducible factor，HIF）是一种促进细胞适应缺氧和缺血的转录因子。长期以来的证据表明，HIF-1α是HIF的一种同种型，其参与多种实体瘤和心脏疾病的发病机制。然而，HIF-1α在视网膜中的作用仍然知之甚少。HIF-1α在脑缺血中具有神经保护作用是近二十年来研究的热点。此外，越来越多的研究表明，HIF-1α及其靶基因有助于视网膜神经保护。本文就HIF-1α及其靶基因在视网膜神经保护中的研究进展作一综述。深入了解HIF-1α及其靶基因的功能可能会发现治疗退行性视网膜疾病的新靶点，包括青光眼、年龄相关性黄斑变性、糖尿病视网膜病变和视网膜静脉阻塞。
Hypoxia-inducible factor (HIF) is a transcription factor that facilitates cellular adaptation to hypoxia and ischemia. Long-standing evidence suggests that one isotype of HIF, HIF-1α, is involved in the pathogenesis of various solid tumors and cardiac diseases. However, the role of HIF-1α in retina remains poorly understood. HIF-1α has been recognized as neuroprotective in cerebral ischemia in the past two decades. Additionally, an increasing number of studies has shown that HIF-1α and its target genes contribute to retinal neuroprotection. This review will focus on recent advances in the studies of HIF-1α and its target genes that contribute to retinal neuroprotection. A thorough understanding of the function of HIF-1α and its target genes may lead to identification of novel therapeutic targets for treating degenerative retinal diseases including glaucoma, age-related macular degeneration, diabetic retinopathy, and retinal vein occlusions.